LIEBERMAN M, KAPLAN H S
Science. 1959 Aug 14;130(3372):387-8. doi: 10.1126/science.130.3372.387.
Cell-free filtrates of x-ray-induced lymphoid tumors of strain C57BL/ Ka mice have elicited, on injection into newborn isologous hosts, a lymphoma incidence of 15 to 19 percent. In control mice of the same subline, the incidence of spontaneous lymphoma is about 1 percent. No leukemogenic activity could be detected in filtrates from thymi harvested at 2 to 32 days following completion of x-ray treatment. Activity was evident at 64 days and was perhaps somewhat greater at 128 days. Serial cell-free passage of filtrates in newborn F(1) hybrid mice resulted in a marked increase in lymphoma incidence (69 percent), coupled with a shortening of the median latency. Supplementary x-irradiation failed to enhance the activity of filtrates after neonatal injection.
将C57BL/Ka品系小鼠经X射线诱导的淋巴瘤无细胞滤液注射到新生的同系宿主中，淋巴瘤发生率为15%至19%。在同一亚系的对照小鼠中，自发性淋巴瘤的发生率约为1%。在X射线治疗结束后2至32天收获的胸腺滤液中未检测到致白血病活性。在64天时活性明显，在128天时可能略高。滤液在新生F(1)杂交小鼠中进行无细胞连续传代后，淋巴瘤发生率显著增加（69%），同时中位潜伏期缩短。新生儿注射后，补充X射线照射未能增强滤液的活性。
