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一种具有P3'→N5'氨基磷酸酯键的新型桥连核酸5'-氨基-2',4'-BNA的合成与性质

Synthesis and properties of a novel bridged nucleic acid with a P3' --> N5' phosphoramidate linkage, 5'-amino-2',4'-BNA.

作者信息

Obika Satoshi, Nakagawa Osamu, Hiroto Akiko, Hari Yoshiyuki, Imanishi Takeshi

机构信息

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

出版信息

Chem Commun (Camb). 2003 Sep 7(17):2202-3. doi: 10.1039/b307290h.

DOI:10.1039/b307290h
PMID:13678201
Abstract

5'-Amino-2',4'-BNA, a novel analogue of BNA series compounds, was successfully synthesized, and its incorporated oligonucleotides showed potent duplex- and triplex-forming ability and resistance against snake venom phosphodiesterase.

摘要

5'-氨基-2',4'-双环核酸（BNA），一种新型的BNA系列化合物类似物，已成功合成，并且其掺入的寡核苷酸显示出强大的双链和三链形成能力以及对蛇毒磷酸二酯酶的抗性。

相似文献

1
Synthesis and properties of a novel bridged nucleic acid with a P3' --> N5' phosphoramidate linkage, 5'-amino-2',4'-BNA.一种具有P3'→N5'氨基磷酸酯键的新型桥连核酸5'-氨基-2',4'-BNA的合成与性质
Chem Commun (Camb). 2003 Sep 7(17):2202-3. doi: 10.1039/b307290h.
2
3'-amino-2',4'-BNA: novel bridged nucleic acids having an N3'-->P5' phosphoramidate linkage.3'-氨基-2',4'-双环核酸：具有N3'→P5'氨基磷酸酯连接的新型桥连核酸。
Chem Commun (Camb). 2001 Oct 7(19):1992-3. doi: 10.1039/b105640a.
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Design, synthesis, and properties of 2',4'-BNA(NC): a bridged nucleic acid analogue.2',4'-双环核苷酸（NC）的设计、合成及性质：一种桥连核酸类似物
J Am Chem Soc. 2008 Apr 9;130(14):4886-96. doi: 10.1021/ja710342q. Epub 2008 Mar 15.
4
Acid-mediated cleavage of oligonucleotide P3' --> N5' phosphoramidates triggered by sequence-specific triplex formation.由序列特异性三链体形成引发的酸介导的寡核苷酸P3'→N5'氨基磷酸酯的切割。
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Synthesis and properties of 5'-amino-2',4'-BNA modified oligonucleotides with P3'-->N5' phosphoramidate linkages.具有3'-磷酰胺基-5'-氮基连接的5'-氨基-2',4'-双环核苷酸修饰寡核苷酸的合成与性质
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Synthesis and properties of 2',4'-BNA(NC), a second generation BNA.第二代BNA——2',4'-BNA(NC)的合成与性质
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Synthesis and properties of a novel bridged nucleic acid analogue, 5'-amino-3',5'-BNA.一种新型桥连核酸类似物5'-氨基-3',5'-BNA的合成与性质
Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1097-100. doi: 10.1081/ncn-200061836.
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Synthesis and properties of a novel bridged nucleic acid analogue bearing a P3'-->N5' phosphoroamidate linkage, 5'-amino-3', 5'-BNA.一种带有P3'→N5'氨基磷酸酯键的新型桥连核酸类似物5'-氨基-3', 5'-BNA的合成与性质
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Synthesis and duplex-forming ability of oligonucleotides modified with 4'-C,5'-C-methylene-bridged nucleic acid (4',5'-BNA).4′-C，5′-C-亚甲基桥接核酸（4′，5′-BNA）修饰的寡核苷酸的合成及双链形成能力。
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Double-stranded DNA-templated cleavage of oligonucleotides containing a P3'->N5' linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity.双链 DNA 模板引导的寡核苷酸断裂，其中包含 P3'->N5' 键，由三链体形成触发：化学修饰的影响和反应性的显著增强。
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Nat Commun. 2022 Jul 12;13(1):4036. doi: 10.1038/s41467-022-31636-2.
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Modified internucleoside linkages for nuclease-resistant oligonucleotides.用于抗核酸酶寡核苷酸的修饰核苷间连接。
RSC Chem Biol. 2020 Dec 8;2(1):94-150. doi: 10.1039/d0cb00136h. eCollection 2021 Feb 1.
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Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications.
氨基甲酸酯锁定核酸（LNA）寡核苷酸的合成及生物物理性质与潜在的反义应用。
Org Biomol Chem. 2019 May 29;17(21):5341-5348. doi: 10.1039/c9ob00691e.
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Cleavage of oligonucleotides containing a P3'→N5' phosphoramidate linkage mediated by single-stranded oligonucleotide templates.寡核苷酸中 P3'→N5' 膦酸酰胺键的断裂由单链寡核苷酸模板介导。
Molecules. 2011 Dec 20;16(12):10695-708. doi: 10.3390/molecules161210695.