Hunter C J, Matyas J R, Duncan N A
McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, AB, Canada.
Tissue Eng. 2003 Aug;9(4):667-77. doi: 10.1089/107632703768247368.
An understanding of developmental biology can provide useful insights into how different tissue-engineered repairs might be designed. During embryogenesis of the intervertebral disk, the cells of the notochord play a critical role in initiating tissue formation, and may be responsible for development of the nucleus pulposus. In some species, including humans, these notochordal cells may eventually be lost, either through apoptosis or terminal differentiation, and are replaced by chondrocyte-like cells. However, there is some evidence that the notochordal cells may persist in at least some humans. This review discusses some of the potential applications of notochordal cells in tissue engineering of the nucleus pulposus.
对发育生物学的理解有助于深入了解如何设计不同的组织工程修复方法。在椎间盘的胚胎发育过程中，脊索细胞在启动组织形成中起关键作用，可能负责髓核的发育。在包括人类在内的一些物种中，这些脊索细胞最终可能通过凋亡或终末分化而丢失，并被软骨样细胞取代。然而，有证据表明，至少在部分人类中，脊索细胞可能会持续存在。本文综述了脊索细胞在髓核组织工程中的一些潜在应用。
