结肠癌根治性切除术后间歇给予香菇多糖增强5-氟尿嘧啶的长期疗效。一项为期7年随访的随机对照试验。
Long-term effect of 5-fluorouracil enhanced by intermittent administration of polysaccharide K after curative resection of colon cancer. A randomized controlled trial for 7-year follow-up.
作者信息
Ito Katsuki, Nakazato Hiroaki, Koike Akihiko, Takagi Hiroshi, Saji Shigetoyo, Baba Shozo, Mai Masayoshi, Sakamoto Jun-ichi, Ohashi Yasuo
机构信息
Department of Surgery 2, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550 Nagoya, Japan.
出版信息
Int J Colorectal Dis. 2004 Mar;19(2):157-64. doi: 10.1007/s00384-003-0532-x. Epub 2003 Sep 12.
BACKGROUND AND AIMS
The efficacy of a biological response modifier polysaccharide K in adjuvant immunochemotherapy was evaluated in primary colon cancer patients with macroscopic Dukes' C after curative resection.
PATIENTS AND METHODS
Employing the minimization method using three factors (lymph node metastases, preoperative serum CEA level, and institution), 446 patients were allocated into groups P and C. Group P received immunochemotherapy, oral PSK (3 g per day) followed by oral 5-FU (200 mg/body per day), while group C received only intermittent chemotherapy, oral 5-FU (200 mg per day) followed by 4-week rest. Both groups received ten courses.
RESULTS
Survival for cancer death was significantly higher in group P than in group C, but there was no difference in 7-year disease-free survival or overall survival had.
CONCLUSION
Repeated alternating administration with PSK followed by 5-FU can improve survival for cancer death.
背景与目的
在根治性切除术后的大体 Dukes' C 期原发性结肠癌患者中，评估生物反应调节剂多糖 K 在辅助免疫化疗中的疗效。
患者与方法
采用最小化法，依据三个因素（淋巴结转移、术前血清癌胚抗原水平和机构），将 446 例患者分为 P 组和 C 组。P 组接受免疫化疗，口服 PSK（每日 3 g）后口服 5-氟尿嘧啶（每日 200 mg/体），而 C 组仅接受间歇化疗，口服 5-氟尿嘧啶（每日 200 mg），随后休息 4 周。两组均接受 10 个疗程。
结果
P 组癌症死亡的生存率显著高于 C 组，但 7 年无病生存率或总生存率无差异。
结论
PSK 与 5-氟尿嘧啶交替重复给药可提高癌症死亡的生存率。
Zotero 插件