Popović L, Oresković K, Zupancić B, Petrunić M, Kunec-Vajić E
Department of Surgery, Clinical Medical Center Rebro, Zagreb, Croatia.
Horm Metab Res. 1998 Mar;30(3):137-40. doi: 10.1055/s-2007-978852.
The relation of plasma lipids and pseudocholinesterase (PChE) activity was studied in rats made hypothyroid by treatment with propylthiouracil (0.05% in drinking water for 28 days) and in hypothyroid patients prior and after L-thyroxine-therapy (1. week 25-50 microg, 2.-4. week 100 microg daily). In rats, thyroid hormone deficiency caused a significant increase in plasma and adipose tissue PChE activity as well as total plasma cholesterol (TC) concentration, and a decrease in plasma triglyceride (TG) concentration. In contrast to rats, thyroid-deficient humans demonstrated a decrease in plasma PChE activity and an increase in both TC and TG, in comparison with euthyroid controls. After one month's therapy with L-thyroxine, reversion of PChE activity and lipid concentrations occurred. The opposite changes of PChE elicited by thyroid hormone deficiency in men and rats are similar to the respective changes in lipoprotein lipase (LPL) activity, observed by other authors. The inverse correlation between both PChE and LPL activity and TG concentration suggests that PChE, similarly to LPL, may be involved in TG hydrolysis.
研究了用丙硫氧嘧啶（饮用水中含0.05%，持续28天）使大鼠甲状腺功能减退，以及甲状腺功能减退患者在左甲状腺素治疗前后（第1周25 - 50微克，第2 - 4周每日100微克）血浆脂质与假性胆碱酯酶（PChE）活性的关系。在大鼠中，甲状腺激素缺乏导致血浆和脂肪组织PChE活性以及血浆总胆固醇（TC）浓度显著增加，血浆甘油三酯（TG）浓度降低。与大鼠相反，甲状腺功能减退的人类与甲状腺功能正常的对照组相比，血浆PChE活性降低，TC和TG均升高。用左甲状腺素治疗一个月后，PChE活性和脂质浓度恢复正常。甲状腺激素缺乏在人和大鼠中引起的PChE相反变化与其他作者观察到的脂蛋白脂肪酶（LPL）活性的相应变化相似。PChE和LPL活性与TG浓度之间的负相关表明，PChE与LPL类似，可能参与TG水解。
