西藏冷杉叶提取物对二氧化硫诱导的小鼠咳嗽反射的镇咳活性。

Antitussive activity of Abies webbiana Lindl. leaf extract against sulphur dioxide-induced cough reflex in mice.

作者信息

Nayak S S, Ghosh A K, Srikanth K, Debnath B, Jha T

机构信息

Natural Science Laboratory, Department of Pharmaceutical Technology, Jadavpur University Kolkata--700 032, India.

出版信息

Phytother Res. 2003 Sep;17(8):930-2. doi: 10.1002/ptr.1263.

DOI:10.1002/ptr.1263

PMID:13680827

Abstract

The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice. When administered orally it exhibited significant antitussive activity compared with the control in a dose dependent manner. The antitussive activity of the extract was compared with that of codeine phosphate, a prototype antitussive agent. The A. webbiana leaf extract (400 and 600 mg/kg) showed maximum inhibition of cough frequency by 71.69% and 78.67%, respectively, when compared with the control group and was comparable in effect to codeine phosphate.

摘要

对韦伯铁线莲（A. webbiana Lindl）的甲醇提取物进行了评估，以研究其对二氧化硫气体诱导的小鼠咳嗽模型的影响。口服给药时，与对照组相比，它以剂量依赖性方式表现出显著的镇咳活性。将该提取物的镇咳活性与原型镇咳药磷酸可待因的活性进行了比较。与对照组相比，韦伯铁线莲叶提取物（400和600mg/kg）分别使咳嗽频率的最大抑制率达到71.69%和78.67%，其效果与磷酸可待因相当。