Chrz M, Benesová E, Ceslar P, Trnĕný M
I. interní klinika 1. lékarské fakulty Univerzity Karlovy, Praha.
Cas Lek Cesk. 1992 Jun 24;131(14):437-42.
The cases of first-degree relatives from five families with hematological malignancies are described in this study. The occurrence of non-Hodgkin's lymphoma (NHL) and B-cell chronic lymphoblastic leukemia (B-CLL) in the first family, NHL and chronic myeloid leukemia (CML) in the second one, two cases of Hodgkin's disease (HD) in the third and the fifth one's NHL and acute myelomonocytic leukemia (AMML) in the fourth one observed. Several factors which are considered to be involved in etiopathogenesis of hematological malignancies (virus infection, immune defects, HL-A antigens, cytogenic features) were discussed. Our study confirm other previous findings, that the familial susceptibility results from a combination of genetic and environmental influences.
本研究描述了来自五个血液系统恶性肿瘤家族的一级亲属病例。在第一个家族中观察到非霍奇金淋巴瘤（NHL）和B细胞慢性淋巴细胞白血病（B-CLL），第二个家族中观察到NHL和慢性粒细胞白血病（CML），第三个家族中有两例霍奇金病（HD），第五个家族中有NHL，第四个家族中有急性粒单核细胞白血病（AMML）。讨论了一些被认为与血液系统恶性肿瘤发病机制有关的因素（病毒感染、免疫缺陷、HL-A抗原、细胞遗传学特征）。我们的研究证实了之前的其他发现，即家族易感性是遗传和环境影响共同作用的结果。
