p53与92千道尔顿和150千道尔顿的蛋白质共享一个抗原决定簇，这些蛋白质可能与人细胞的衰老有关。
p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells.
作者信息
van den Heuvel S J, The S I, Klein B, Jochemsen A G, Zantema A, van der Eb A J
机构信息
Laboratory of Molecular Carcinogenesis, Sylvius Laboratory, University of Leiden, The Netherlands.
出版信息
J Virol. 1992 Jan;66(1):591-5. doi: 10.1128/JVI.66.1.591-595.1992.
Abstract
A panel of primary human cells and virus-transformed derivatives were tested for events that coincide with immortalization. In all primary and precrisis cells, two proteins of 92 and 150 kDa that shared an epitope with p53 were found; in most of their immortalized derivatives, however, they were absent. Expression of these proteins may be involved in senescence.
摘要
对一组原代人细胞和病毒转化衍生物进行了与永生化相关事件的检测。在所有原代细胞和危机前细胞中，发现了两种与p53共享一个表位的92 kDa和150 kDa蛋白质；然而，在它们的大多数永生化衍生物中，这些蛋白质并不存在。这些蛋白质的表达可能与衰老有关。
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