产黑色素拟杆菌和口腔拟杆菌菌株中的β-内酰胺酶活性。
Beta-Lactamase activity in strains of Bacteroides melaninogenicus and Bacteroides oralis.
作者信息
Salyers A A, Wong J, Wilkins T D
出版信息
Antimicrob Agents Chemother. 1977 Jan;11(1):142-6. doi: 10.1128/AAC.11.1.142.
Abstract
beta-Lactamase from strains of Bacteroides melaninogenicus and Bacteroides oralis hydrolyzed penicillin more rapidly than ampicillin or carbenicillin. Cephalothin and a chromogenic cephalosporin (87/312) were also hydrolyzed by the enzyme. Activity was found only in beta-lactam-resistant strains, but there was considerable variation in activity among strains having the same minimal inhibitory concentrations of antibiotic. beta-Lactamase activity was cell bound and appeared to be tightly associated with the cell envelope since detergents were required to elute this activity.
摘要
产黑色素拟杆菌和口腔拟杆菌菌株产生的β-内酰胺酶对青霉素的水解速度比对氨苄西林或羧苄西林更快。头孢噻吩和一种显色头孢菌素（87/312）也被该酶水解。仅在对β-内酰胺耐药的菌株中发现有活性，但在具有相同抗生素最低抑菌浓度的菌株中，活性存在相当大的差异。β-内酰胺酶活性与细胞结合，似乎与细胞膜紧密相关，因为需要用去污剂洗脱这种活性。
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