Weinrich A E, Del bene V E
Antimicrob Agents Chemother. 1976 Jul;10(1):106-11. doi: 10.1128/AAC.10.1.106.
A diverse group of anaerobic bacteria representing a spectrum of resistance to beta-lactam antibiotics was studied to characterize their beta-lactamase activity and relate it to resistance. The Bacteroides fragilis organisms had moderate resistance and produced a cephalosporinase with low activity. The Clostridium ramosum was intermediate in resistance and had intermediate, inducible beta-lactamase activity. The B. clostridiiformis organism was highly resistant, produced a potent inducible penicillinase, and had a barrier to the penicillin substrates. Only the beta-lactamase of C. ramosum fit Richmond's classification (class IV). Although there was a rough correlation between beta-lactamase activity and antibiotic resistance, other mechanisms are undoubtedly involved in determining resistance levels.
研究了一组对β-内酰胺抗生素具有不同耐药性的厌氧细菌，以表征它们的β-内酰胺酶活性并将其与耐药性相关联。脆弱拟杆菌具有中等耐药性，并产生低活性的头孢菌素酶。多枝梭菌耐药性中等，具有中等的、可诱导的β-内酰胺酶活性。梭状芽孢杆菌高度耐药，产生强效的可诱导青霉素酶，并且对青霉素底物有屏障作用。只有多枝梭菌的β-内酰胺酶符合里士满分类（IV类）。尽管β-内酰胺酶活性与抗生素耐药性之间存在大致的相关性，但其他机制无疑也参与了耐药水平的决定。
