Boekhoff I, Breer H
University Stuttgart-Hohenheim, Institute of Zoophysiology, Stuttgart, Federal Republic of Germany.
Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):471-4. doi: 10.1073/pnas.89.2.471.
By using isolated rat olfactory cilia and a fast kinetics methodology, it has been demonstrated that odorant-induced second messenger signaling in the millisecond time range is terminated via phosphorylation reactions catalyzed by specific protein kinases. The cyclic adenosine nucleotide pathway is turned off by kinase A activity, whereas the inositol trisphosphate cascade is terminated by kinase C. The data support the concept that desensitization of odorant responses involves phosphorylation of key elements in the transduction cascade.