嗅觉中第二信使信号传导的终止。
Termination of second messenger signaling in olfaction.
作者信息
Boekhoff I, Breer H
机构信息
University Stuttgart-Hohenheim, Institute of Zoophysiology, Stuttgart, Federal Republic of Germany.
出版信息
Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):471-4. doi: 10.1073/pnas.89.2.471.
Abstract
By using isolated rat olfactory cilia and a fast kinetics methodology, it has been demonstrated that odorant-induced second messenger signaling in the millisecond time range is terminated via phosphorylation reactions catalyzed by specific protein kinases. The cyclic adenosine nucleotide pathway is turned off by kinase A activity, whereas the inositol trisphosphate cascade is terminated by kinase C. The data support the concept that desensitization of odorant responses involves phosphorylation of key elements in the transduction cascade.
摘要
通过使用分离的大鼠嗅觉纤毛和快速动力学方法，已证明在毫秒时间范围内，气味剂诱导的第二信使信号传导是通过特定蛋白激酶催化的磷酸化反应终止的。环腺苷酸途径由激酶A活性关闭，而三磷酸肌醇级联反应由激酶C终止。这些数据支持了气味剂反应脱敏涉及转导级联中关键元件磷酸化的概念。
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本文引用的文献
1
ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes.三磷酸腺苷（ATP）介导视觉受体膜中环状鸟苷酸磷酸二酯酶激活的快速逆转。
Nature. 1980 Oct 23;287(5784):734-6. doi: 10.1038/287734a0.
2
3
4
A partially purified preparation of isolated chemosensory cilia from the olfactory epithelium of the bullfrog, Rana catesbeiana.一种从牛蛙（北美牛蛙）嗅觉上皮中分离出的化学感受纤毛的部分纯化制剂。
J Neurosci. 1986 Jul;6(7):1962-9. doi: 10.1523/JNEUROSCI.06-07-01962.1986.
5
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.鞘氨醇在体外及人血小板中对蛋白激酶C活性和佛波醇二丁酸酯结合的抑制作用。
J Biol Chem. 1986 Sep 25;261(27):12604-9.
6
Isolated frog olfactory cilia: a preparation of dendritic membranes from chemosensory neurons.分离的青蛙嗅觉纤毛：一种来自化学感应神经元的树突膜制剂。
J Neurosci. 1986 Aug;6(8):2146-54. doi: 10.1523/JNEUROSCI.06-08-02146.1986.
7
Regulation of transmembrane signaling by receptor phosphorylation.受体磷酸化对跨膜信号传导的调控。
Cell. 1987 Mar 27;48(6):913-22. doi: 10.1016/0092-8674(87)90700-8.
8
Odor-induced membrane currents in vertebrate-olfactory receptor neurons.脊椎动物嗅觉受体神经元中气味诱导的膜电流。
Science. 1989 Apr 7;244(4900):79-82. doi: 10.1126/science.2704991.
9
Development of a novel, Ins(1,4,5)P3-specific binding assay. Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes.
Cell Signal. 1989;1(2):147-56. doi: 10.1016/0898-6568(89)90004-1.
10
Vertebrate olfactory reception.脊椎动物的嗅觉接收。
Annu Rev Neurosci. 1986;9:329-55. doi: 10.1146/annurev.ne.09.030186.001553.
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