Gunning W T, Goldblatt P J, Stoner G D
Department of Pathology, Medical College of Ohio, Toledo 43699-0008.
Am J Pathol. 1992 Jan;140(1):109-18.
Chemically induced mouse lung tumors exhibit distinctive growth patterns, characterized by an alveolar or solid appearance, a papillary appearance, or a combination of the two. Lung tumors induced in strain A/J mice by either benzo(a)pyrene (BP) or by N-nitrosoethylurea (ENU) were examined for expression of low- and high-molecular-weight cytokeratins. Simple cytokeratins (low molecular weight) were found in all epithelial cells of the normal mouse lung and in all tumor types, whereas higher-molecular-weight cytokeratins were found only in normal bronchiolar cells and in papillary tumor cells. These data lend support to the hypothesis that chemically induced papillary lung tumors in strain A/J mice are derived from bronchiolar Clara cells.
化学诱导的小鼠肺癌呈现出独特的生长模式，其特征为肺泡样或实体样外观、乳头样外观，或两者兼具。对用苯并(a)芘（BP）或N-亚硝基乙基脲（ENU）诱导A/J品系小鼠产生的肺癌进行了低分子量和高分子量细胞角蛋白表达检测。正常小鼠肺的所有上皮细胞以及所有肿瘤类型中均发现了简单细胞角蛋白（低分子量），而高分子量细胞角蛋白仅在正常细支气管细胞和乳头状肿瘤细胞中发现。这些数据支持了这样一种假说，即化学诱导的A/J品系小鼠乳头状肺癌源自细支气管克拉拉细胞。
