鼠伤寒沙门氏菌/哺乳动物微粒体系统中吡咯里西啶生物碱的致突变性。

Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system.

作者信息

Rubiolo P, Pieters L, Calomme M, Bicchi C, Vlietinck A, Vanden Berghe D

机构信息

Dipartimento di Scienza e Technologia del Farmaco, Universitá delgi Studi di Torino, Turin, Italy.

出版信息

Mutat Res. 1992 Feb;281(2):143-7. doi: 10.1016/0165-7992(92)90050-r.

DOI:10.1016/0165-7992(92)90050-r

PMID:1370983

Abstract

The mutagenicity of a series of pyrrolizidine alkaloids, and of extracts from several Italian Senecio species containing pyrrolizidine alkaloids, including S. inaequidens, S. fuchsii and S. cacaliaster, were tested using the Salmonella typhimurium/mammalian microsome system. Retrorsine, senecivernine, seneciphylline and the Senecio extracts showed a weakly mutagenic activity.

摘要

使用鼠伤寒沙门氏菌/哺乳动物微粒体系统测试了一系列吡咯里西啶生物碱以及几种含有吡咯里西啶生物碱的意大利千里光属植物提取物的致突变性，这些植物包括不等齿千里光、富氏千里光和假菊叶千里光。倒千里光碱、千里光毒碱、千里光菲灵碱以及千里光属植物提取物显示出弱致突变活性。