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饥饿和重新喂食期间骨骼肌和棕色脂肪组织中葡萄糖转运蛋白的表达及葡萄糖利用情况。

Glucose transporter expression and glucose utilization in skeletal muscle and brown adipose tissue during starvation and re-feeding.

作者信息

Smith D M, Bloom S R, Sugden M C, Holness M J

机构信息

Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

出版信息

Biochem J. 1992 Feb 15;282 ( Pt 1)(Pt 1):231-5. doi: 10.1042/bj2820231.

DOI:10.1042/bj2820231
PMID:1371667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1130912/
Abstract

Starvation (48 h) decreased the concentration of mRNA of the insulin-responsive glucose transporter isoform (GLUT 4) in interscapular brown adipose tissue (IBAT) (56%) and tibialis anterior (10%). Despite dramatic [7-fold (tibialis anterior) and 40-fold (IBAT)] increases in glucose utilization after 2 and 4 h of chow re-feeding, no significant changes in GLUT 4 mRNA concentration were observed in these tissues over this re-feeding period. The results exclude changes in GLUT 4 mRNA concentration in mediating the responses of glucose transport in these tissues to acute re-feeding after prolonged starvation.

摘要

饥饿（48小时）降低了肩胛间棕色脂肪组织（IBAT）（56%）和胫前肌（10%）中胰岛素反应性葡萄糖转运异构体（GLUT 4）的mRNA浓度。尽管在重新喂食饲料2小时和4小时后葡萄糖利用率显著增加[胫前肌增加7倍，IBAT增加40倍]，但在重新喂食期间这些组织中GLUT 4 mRNA浓度未观察到显著变化。这些结果排除了GLUT 4 mRNA浓度变化在介导这些组织中葡萄糖转运对长期饥饿后急性重新喂食的反应中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4073/1130912/d156e211624a/biochemj00141-0231-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4073/1130912/77c9ab5a6401/biochemj00141-0230-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4073/1130912/6015d40eebb6/biochemj00141-0231-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4073/1130912/d156e211624a/biochemj00141-0231-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4073/1130912/77c9ab5a6401/biochemj00141-0230-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4073/1130912/6015d40eebb6/biochemj00141-0231-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4073/1130912/d156e211624a/biochemj00141-0231-b.jpg

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本文引用的文献

1
Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.胰岛素对分离的大鼠脂肪细胞葡萄糖转运作用的潜在机制。细胞内转运系统向质膜的明显易位。
J Biol Chem. 1980 May 25;255(10):4758-62.
2
Effect of long chain triglyceride infusion on glucose metabolism in man.长链甘油三酯输注对人体葡萄糖代谢的影响。
Metabolism. 1982 Nov;31(11):1128-36. doi: 10.1016/0026-0495(82)90163-9.
3
Potential mechanism of insulin action on glucose transport in the isolated rat diaphragm. Apparent translocation of intracellular transport units to the plasma membrane.
Br J Pharmacol. 2000 Apr;129(8):1787-93. doi: 10.1038/sj.bjp.0703266.
4
Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.瘦素能迅速抑制胰岛素瘤细胞、大鼠和人类胰岛以及小鼠体内胰岛素的释放。
J Clin Invest. 1997 Dec 1;100(11):2729-36. doi: 10.1172/JCI119818.
5
Hormonal regulation of glucose transport in a brown adipose cell preparation isolated from rats that shows a large response to insulin.从对胰岛素有强烈反应的大鼠中分离出的棕色脂肪细胞制剂中葡萄糖转运的激素调节。
Biochem J. 1996 Apr 1;315 ( Pt 1)(Pt 1):25-31. doi: 10.1042/bj3150025.
6
Physiological modulation of the uptake and fate of glucose in brown adipose tissue.棕色脂肪组织中葡萄糖摄取与代谢的生理调节
Biochem J. 1993 Oct 1;295 ( Pt 1)(Pt 1):171-6. doi: 10.1042/bj2950171.
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J Biol Chem. 1981 Jul 25;256(14):7090-3.
4
Terminal transferase-catalyzed addition of nucleotides to the 3' termini of DNA.末端转移酶催化的核苷酸添加到DNA的3'末端。
Methods Enzymol. 1980;65(1):43-62. doi: 10.1016/s0076-6879(80)65009-5.
5
The maximum capacity of glycolysis in brown adipose tissue and its relationship to control of the blood glucose concentration.棕色脂肪组织中糖酵解的最大能力及其与血糖浓度控制的关系。
FEBS Lett. 1982 Nov 8;148(2):198-200. doi: 10.1016/0014-5793(82)80807-7.
6
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat.一种在麻醉大鼠的骨骼肌和白色脂肪组织中定量体内葡萄糖利用的方法。
Biochem J. 1985 May 15;228(1):103-10. doi: 10.1042/bj2280103.
7
Muscle glucose metabolism in exercising rats: comparison with insulin stimulation.运动大鼠的肌肉葡萄糖代谢：与胰岛素刺激的比较。
Am J Physiol. 1985 May;248(5 Pt 1):E575-80. doi: 10.1152/ajpendo.1985.248.5.E575.
8
Effects of fasting on tissue glucose utilization in conscious resting rats. Major glucose-sparing effect in working muscles.禁食对清醒静止大鼠组织葡萄糖利用的影响。工作肌肉中的主要葡萄糖节省效应。
Biochem J. 1987 Aug 15;246(1):241-4. doi: 10.1042/bj2460241.
9
Stimulatory effect of cold adaptation on glucose utilization by brown adipose tissue. Relationship with changes in the glucose transporter system.冷适应对棕色脂肪组织葡萄糖利用的刺激作用。与葡萄糖转运系统变化的关系。
J Biol Chem. 1987 Jun 5;262(16):7732-6.
10
Glucose utilization in vivo and insulin-sensitivity of rat brown adipose tissue in various physiological and pathological conditions.不同生理和病理条件下大鼠棕色脂肪组织的体内葡萄糖利用及胰岛素敏感性
Biochem J. 1986 Jan 1;233(1):249-52. doi: 10.1042/bj2330249.