Hume R, Vallance B D, Muir M M
J Clin Pathol. 1982 Feb;35(2):195-9. doi: 10.1136/jcp.35.2.195.
Leucocyte ascorbate (LA) and serum ascorbate (SA) were measured in patients who had sustained an acute cerebrovascular accident. There was a significant fall in LA and Sa within 24 hours of the incident and this persisted for several weeks. The "stress" of the event resulted in a rise in serum cortisol concentration and depletion of both pituitary and adrenal glands of ascorbate when examined at post mortem. Serum fibrinogen concentrations also rose above normal. The role of ascorbate in pituitary and adrenal function and the relation of ascorbate to acute and chronic vascular disorders has still to be established.
对发生急性脑血管意外的患者测定了白细胞中的抗坏血酸（LA）和血清中的抗坏血酸（SA）。事件发生后24小时内，LA和SA显著下降，且这种情况持续了数周。该事件的“应激”导致血清皮质醇浓度升高，尸检时发现垂体和肾上腺中的抗坏血酸均减少。血清纤维蛋白原浓度也高于正常水平。抗坏血酸在垂体和肾上腺功能中的作用以及抗坏血酸与急慢性血管疾病的关系仍有待确定。
