白细胞介素10是活化的人B淋巴细胞的一种强效生长和分化因子。
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.
作者信息
Rousset F, Garcia E, Defrance T, Péronne C, Vezzio N, Hsu D H, Kastelein R, Moore K W, Banchereau J
机构信息
Schering-Plough, Laboratory for Immunological Research, Dardilly, France.
出版信息
Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1890-3. doi: 10.1073/pnas.89.5.1890.
Abstract
Interleukin 10 (IL-10), originally identified as a TH2 helper T-cell product able to inhibit cytokine production by TH1 cells, is highly homologous to BCRF1 (viral IL-10), an open reading frame in the Epstein-Barr virus genome. Here, we show that human and viral IL-10 stimulate DNA replication of B lymphocytes activated either via their antigen receptor or via their CD40 antigen. IL-4 and IL-10 display additive effects and induce a strong increase in the number of viable cells. Moreover, IL-10 induces activated B cells to secrete large amounts of IgG, IgA, and IgM, and the combination of IL-10 and IL-4 results in the secretion of the four immunoglobulin isotypes. Thus, IL-10 may play an important role in the amplification of humoral responses.
摘要
白细胞介素10（IL-10）最初被鉴定为一种能够抑制TH1细胞产生细胞因子的TH2辅助性T细胞产物，它与EB病毒基因组中的一个开放阅读框BCRF1（病毒IL-10）高度同源。在此，我们表明人和病毒IL-10可刺激通过其抗原受体或通过其CD40抗原激活的B淋巴细胞的DNA复制。IL-4和IL-10显示出相加效应，并诱导活细胞数量大幅增加。此外，IL-10诱导活化的B细胞分泌大量的IgG、IgA和IgM，并且IL-10与IL-4的组合导致四种免疫球蛋白同种型的分泌。因此，IL-10可能在体液免疫反应的放大中起重要作用。
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