经乙醚处理后获得的流感病毒成分的物理和生物学特性。

Physical and biological properties of influenza virus components obtained after ether treatment.

作者信息

DAVENPORT F M, ROTT R, SCHAEFER W

出版信息

J Exp Med. 1960 Nov 1;112(5):765-82. doi: 10.1084/jem.112.5.765.

DOI:10.1084/jem.112.5.765

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2137308/

Abstract

The Rostock strain of fowl plague, the swine, A, A', and Asian strains of influenza A as well as their hemagglutinin and internal s antigen subunits obtained after ether splitting, were found to be morphologically indistinguishable when examined simultaneously. Hemagglutinin fractions reacted in a highly strain specific manner when tested by hemagglutination inhibition or by complement fixation using sera obtained after infection. With the same sera internal s antigen fractions were shown to be serologically distinguishable by complement fixation. This observation may stimulate interest in the feasibility of employing immunologic techniques for the study of nucleoproteins. The significance of the findings reported is discussed.

摘要

同时检查时发现，鸡瘟罗斯托克毒株、甲型流感的猪型、A 型、A'型及亚洲型毒株，以及经乙醚裂解后得到的它们的血凝素和内部 s 抗原亚基，在形态上无法区分。当用感染后获得的血清通过血凝抑制试验或补体结合试验检测时，血凝素组分以高度毒株特异性的方式发生反应。用同样的血清，通过补体结合试验表明内部 s 抗原组分在血清学上是可区分的。这一观察结果可能会激发人们对采用免疫技术研究核蛋白可行性的兴趣。文中讨论了所报道发现的意义。

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