Buchwald J S, Erwin R, Van Lancker D, Guthrie D, Schwafel J, Tanguay P
Department of Physiology, UCLA School of Medicine 90024.
Electroencephalogr Clin Neurophysiol. 1992 Mar-Apr;84(2):164-71. doi: 10.1016/0168-5597(92)90021-3.
MLR recordings from a group of 11 high-functioning adult autistic subjects were compared with those from a control group of 11 normal subjects. Components selected for analysis were "Pa", the maximum positivity in the 25-40 msec latency range following stimulus onset, "P1", the maximum positivity within the 50-65 msec latency range, and "Nb," the maximum negative deflection in the 40-50 msec latency range. Statistical analyses of amplitude and latency data were conducted using repeated measures analysis of variance and t test group comparisons. The Pa component showed no significant difference between autistic and control groups. However, 2 types of abnormality were noted in the P1 component: (1) the P1 component was significantly smaller in the autistic subjects at slow rates of stimulation, and (2) the autistic P1 did not change as rates of click stimulation increased from 0.5 to 10/sec, in contrast to the normally produced P1 decrement. Data from the P1 model in the cat, and complementary data from the human, closely link the generator substrate of the P1 potential to cholinergic components of the ascending reticular activating system (RAS) and their thalamic target cells. This is the first report of abnormal P1 responses in autism and strongly suggests that the RAS and/or its post-synaptic thalamic targets may be dysfunctional in this syndrome.
对一组11名高功能成年自闭症受试者的中潜伏期反应（MLR）记录与11名正常受试者的对照组记录进行了比较。选择用于分析的成分包括“Pa”，即刺激开始后25 - 40毫秒潜伏期范围内的最大正向波；“P1”，即50 - 65毫秒潜伏期范围内的最大正向波；以及“Nb”，即40 - 50毫秒潜伏期范围内的最大负向波。使用重复测量方差分析和t检验组比较对振幅和潜伏期数据进行统计分析。Pa成分在自闭症组和对照组之间没有显著差异。然而，在P1成分中发现了两种异常情况：（1）在慢刺激率下，自闭症受试者的P1成分明显较小；（2）与正常产生的P1衰减相反，随着点击刺激率从0.5增加到10次/秒，自闭症受试者的P1没有变化。猫的P1模型数据以及来自人类的补充数据，将P1电位的发生器基质与上行网状激活系统（RAS）的胆碱能成分及其丘脑靶细胞紧密联系起来。这是关于自闭症中P1反应异常的首次报告，并强烈表明RAS和/或其突触后丘脑靶标在该综合征中可能功能失调。
