Erwin R J, Buchwald J S
Electroencephalogr Clin Neurophysiol. 1986 Nov;64(5):417-23. doi: 10.1016/0013-4694(86)90075-1.
Middle latency responses (MLRs), in the 10-100 msec latency range evoked by click stimuli, were examined in two sets of 7 adult subjects utilizing 5 randomly ordered rates of stimulus presentation: 0.5/sec, 1/sec, 5/sec, 8/sec and 10/sec. Evoked potentials were collected in 250 trial averages for each rate, and a replication across rates yielded 500 trial averages. Peak-to-peak measurements for Pa-Nb and P1-Nb components revealed that the P1 component was reduced in amplitude or absent at the faster rates, while the amplitude of the Pa component remained unchanged across rates. In addition, the latency of Pa was significantly longer for the faster rates of stimulation. These findings were similar across both mastoid and sternovertebral references. Taken together with previous work, these data suggest that the human Pa and P1 potentials reflect different generator systems. Moreover, the physiological similarities between the human P1 potential and the cat wave A suggest that in the human, as in the cat, this potential may be generated within the ascending reticular activating system, whereas the physiological similarities between the human Pa and the cat wave 7, as well as previous clinical data, suggest an auditory cortex origin of this component.
对两组共7名成年受试者进行了研究，利用5种随机排序的刺激呈现速率（0.5次/秒、1次/秒、5次/秒、8次/秒和10次/秒），检测由点击刺激诱发的潜伏期在10 - 100毫秒范围内的中潜伏期反应（MLR）。每种速率下均采集250次平均诱发电位，各速率重复测量得到500次平均诱发电位。对Pa - Nb和P1 - Nb成分进行峰峰值测量发现，在较快速率下P1成分的波幅减小或消失，而Pa成分的波幅在各速率下保持不变。此外，在较快的刺激速率下，Pa的潜伏期明显更长。在乳突和胸骨脊椎参考点上，这些发现都是相似的。结合之前的研究工作，这些数据表明人类的Pa和P1电位反映了不同的发生器系统。此外，人类P1电位与猫的A波在生理上的相似性表明，在人类中，如同在猫中一样，该电位可能在上升网状激活系统中产生，而人类Pa与猫的7波在生理上的相似性以及之前的临床数据表明该成分起源于听觉皮层。
