Gastaldo L, Ciabatti R, Assi F, Restelli E, Kettenring J K, Zerilli L F, Romanò G, Denaro M, Cavalleri B
Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano, Italy.
J Ind Microbiol. 1992 Nov;11(1):13-8. doi: 10.1007/BF01583726.
When Actinoplanes strain ATCC 33076, the producer of A-16686 A1, A2 and A3 complex, is fermented in a suitable medium three additional factors, designated A' 1, A' 2 and A' 3 are produced. These were isolated and characterized, and were shown to differ from the parent components of the original complex by lacking one mannose unit. Bioconversion of A factors into A' factors was achieved by incubation with the mycelium of Actinoplanes ATCC 33076. Factor A' 2 has better antibacterial activity than A2 against some bacteria.
当阿维链霉菌菌株ATCC 33076（A - 16686 A1、A2和A3复合物的产生菌）在合适的培养基中发酵时，会产生另外三种因子，分别命名为A'1、A'2和A'3。这些因子被分离并进行了表征，结果表明它们与原始复合物的母体成分不同，缺少一个甘露糖单元。通过与阿维链霉菌ATCC 33076的菌丝体孵育，实现了A因子向A'因子的生物转化。因子A'2对某些细菌的抗菌活性比A2更好。
