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Micronucleus tests on N-ethyl-N-nitrosourea with mouse peripheral blood reticulocytes using acridine orange-coated slides.

作者信息

Hitotsumachi S, Kimura Y, Katoh M, Ishihara N, Hara T, Shibuya T

机构信息

Drug Safety Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.

出版信息

Mutat Res. 1992 Feb-Mar;278(2-3):113-5.

PMID:1372691
Abstract

The micronucleus test with peripheral blood using acridine orange-coated slides was validated in male CD-1 mice treated once with N-ethyl-N-nitrosourea (ENU) at doses of 6.25, 12.5, 25.0, and 50.0 mg/kg body weight. Peripheral blood preparations were made 0, 24, 48, and 72 h after treatment. The frequencies of micronucleated peripheral reticulocytes in the ENU-treated groups increased dose-dependently, peaking at 48 h after treatment. The results indicate that the method used in the present study can be an alternative to the method using bone marrow polychromatic erythrocytes.

摘要

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