比利时全科医疗中丙型肝炎的血清流行病学特征。

Sero epidemiological characteristics of hepatitis C encountered in general practice in Belgium.

作者信息

Vranckx R, Walckiers D, Stroobant A, Thiers G

机构信息

Institute of Hygiene and Epidemiology, Brussels, Belgium.

出版信息

Eur J Clin Microbiol Infect Dis. 1992 Jan;11(1):62-4. doi: 10.1007/BF01971275.

DOI:10.1007/BF01971275

PMID:1373384

Abstract

A study carried out between 1982 and 1984 established by exclusion diagnosis that 35% of viral hepatitis cases registered in Belgium were due to non A, non B (NANB) viruses. Recently, a new anti-hepatitis C virus (HCV) detection test was used to analyse the sera of patients in whom NANB hepatitis was diagnosed in that study. Using this new serological test for HCV, 29% of the NANB group was found to be positive for anti-HCV. In the 1982-84 study on viral hepatitis diagnosed by general practitioners, the number of clinically recognized infections was estimated at 14,700 (+/- 2,170; confidence interval at 95%) per year. By combining these data and the results of the present study, the following estimates could be calculated: HAV (7,129 +/- 1,054/year), HBV (2,426 +/- 358/year), HCV (1,470 +/- 216/year) and non-identified hepatitis viruses (3,675 +/- 543/year).

摘要

1982年至1984年间开展的一项研究通过排除诊断确定，比利时登记的病毒性肝炎病例中有35%是由非甲非乙型（NANB）病毒引起的。最近，一种新的抗丙型肝炎病毒（HCV）检测试验被用于分析在该研究中被诊断为NANB肝炎的患者的血清。使用这种新的HCV血清学检测方法，发现NANB组中有29%的患者抗HCV呈阳性。在1982 - 1984年由全科医生诊断的病毒性肝炎研究中，每年临床确诊的感染病例数估计为14,700例（±2,170；95%置信区间）。通过综合这些数据和本研究的结果，可以计算出以下估计值：甲型肝炎病毒（每年7,129±1,054例）、乙型肝炎病毒（每年2,426±358例）、丙型肝炎病毒（每年1,470±216例）和未确定的肝炎病毒（每年3,675±543例）。