CD8+皮肤间变性大细胞淋巴瘤：两例病例报告，包括免疫表型分析、T细胞受体基因重排及电子显微镜研究
CD8+ cutaneous anaplastic large-cell lymphoma: report of two cases with immunophenotyping, T-cell-receptor gene rearrangement and electron microscopic studies.
作者信息
Kikuchi A, Sakuraoka K, Kurihara S, Akiyama M, Shimizu H, Nishikawa T
机构信息
Department of Dermatology, Saiseikai Yokomashi Nanbu Hospital, Kanagawa, Japan.
出版信息
Br J Dermatol. 1992 Apr;126(4):404-8. doi: 10.1111/j.1365-2133.1992.tb00690.x.
Abstract
Two cases are reported of cutaneous anaplastic large-cell lymphoma with the suppressor/cytotoxic (CD8) phenotype. In both cases there was a solitary skin tumour in which there was a dense infiltrate with large irregularly shaped cells which on immunophenotyping expressed CD8. DNA hybridization analysis showed rearrangements of the T-cell-receptor gene in both cases.
摘要
报告了两例具有抑制性/细胞毒性（CD8）表型的皮肤间变性大细胞淋巴瘤。两例均有一个孤立性皮肤肿瘤，其中有大量形态不规则的细胞密集浸润，免疫表型分析显示这些细胞表达CD8。DNA杂交分析表明两例均有T细胞受体基因重排。
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