Krishnan J, Tomaszewski M M, Kao G F
Department of Hematologic and Lymphatic Pathology, Armed Forces Institute of Pathology, Washington, D.C 20306-6000.
J Cutan Pathol. 1993 Jun;20(3):193-202. doi: 10.1111/j.1600-0560.1993.tb00643.x.
The clinical, morphological and immunohistochemical features of 27 patients with anaplastic large cell lymphoma (ALCL) of CD30-positive type, with cutaneous lesions as the sole initial clinical manifestation, were analyzed. The neoplasm presented as solitary or multiple, usually ulcerated skin lesions, affecting predominantly elderly patients (median age: 67 years) with a male preponderance (male to female ratio of 6:1). In most patients, there was an excellent response to chemotherapy. The cardinal histological features included diffuse dermal and subcutaneous infiltration by large, anaplastic tumor cells, all or nearly all of which showed diffuse, strong membrane staining and frequently a paranuclear, dot-like reaction with the CD30 marker (Ber-H2). Epidermal ulceration, pseudo-epitheliomatous hyperplasia and dermal vascular proliferation were also observed.
分析了27例以皮肤损害为唯一首发临床表现的CD30阳性型间变性大细胞淋巴瘤（ALCL）患者的临床、形态学及免疫组化特征。肿瘤表现为单发或多发，通常为溃疡型皮肤损害，主要累及老年患者（中位年龄：67岁），男性居多（男女比例为6:1）。大多数患者对化疗反应良好。主要组织学特征包括真皮和皮下有大的间变性肿瘤细胞弥漫浸润，所有或几乎所有肿瘤细胞均显示弥漫性强膜染色，且常与CD30标记物（Ber-H2）呈核旁点状反应。还观察到表皮溃疡、假上皮瘤样增生及真皮血管增生。
