Noorduyn L A, van Heerde P, Meyer C J
Department of Pathology, Netherlands Cancer Institute, Amsterdam.
Cytopathology. 1990;1(5):297-304. doi: 10.1111/j.1365-2303.1990.tb00363.x.
To study the cytomorphology of Ki-1 (CD-30) positive anaplastic large cell lymphoma, imprints and fine needle aspirates from a total of 20 of these tumours were collected. The results show that these tumours have a highly pleomorphic and variable picture, which can be easily confused with other poorly differentiated large cell tumours. Typical morphological differences between the B-cell and T-cell variety were found. B-cell tumours more often showed nuclear multilobation, a fine, hypochromatic chromatin pattern, and many lymphoglandular bodies. T-cell tumours more often displayed multinucleation, window nuclei, and a hyperchromatic coarse chromatin pattern. The diagnosis of anaplastic large cell Ki-1 positive lymphoma, B-cell type or T-cell type, should be included in the differential diagnosis of any large cell tumour of uncertain origin with mainly dissociated tumour cells. Immunocytochemistry is recommended to establish the correct diagnosis.
为研究Ki-1（CD-30）阳性间变性大细胞淋巴瘤的细胞形态学，收集了总共20例此类肿瘤的印片和细针穿刺样本。结果显示，这些肿瘤具有高度多形性且表现各异，很容易与其他低分化大细胞肿瘤混淆。发现了B细胞型和T细胞型之间典型的形态学差异。B细胞肿瘤更常表现为核多叶、细的、淡染的染色质模式以及许多淋巴腺小体。T细胞肿瘤更常表现为多核、核窗以及深染的粗糙染色质模式。在鉴别诊断任何起源不明且主要为散在肿瘤细胞的大细胞肿瘤时，应考虑诊断B细胞型或T细胞型间变性大细胞Ki-1阳性淋巴瘤。建议采用免疫细胞化学来确立正确诊断。
