Ragheb S, Lisak R P
Department of Neurology, Wayne State University, Detroit, MI.
Neurology. 1992 May;42(5):1076-80. doi: 10.1212/wnl.42.5.1076.
CD5+ B cells comprise a subset of B lymphocytes that may play a pathogenetic role in the development of human autoimmune disease. We previously reported a high-frequency phenotype (greater than 30% CD5+ B cells) in the peripheral blood of 57% of myasthenia gravis (MG) patients and 13% of controls. We have now examined additional patients (n = 41) and controls (n = 27) and continue to find that 44% of MG patients have a high-frequency phenotype of CD5+ B cells compared with 7% of controls. Serial studies showed that the frequency of CD5+ B cells in peripheral blood remained fairly stable for controls and that it may decrease with immunosuppressive therapy of MG patients. In patients receiving anticholinesterase only or no therapy (n = 21), the age at onset of MG, presence or absence of detectable serum anti-acetylcholine receptor antibody, clinical extent of MG, and the duration of disease may affect the frequency of CD5+ B cells in the blood.
CD5⁺ B细胞是B淋巴细胞的一个亚群，可能在人类自身免疫性疾病的发生发展中起致病作用。我们之前报道过，57%的重症肌无力（MG）患者外周血中存在高频表型（超过30%的CD5⁺ B细胞），而对照组中这一比例为13%。我们现在检查了更多患者（n = 41）和对照组（n = 27），继续发现44%的MG患者有CD5⁺ B细胞高频表型，而对照组为7%。系列研究表明，对照组外周血中CD5⁺ B细胞频率保持相当稳定，而MG患者接受免疫抑制治疗后该频率可能降低。在仅接受抗胆碱酯酶治疗或未接受治疗的患者（n = 21）中，MG的发病年龄、是否可检测到血清抗乙酰胆碱受体抗体、MG的临床严重程度以及病程可能影响血液中CD5⁺ B细胞的频率。
