重症肌无力患者与健康个体之间的CD5 + B淋巴细胞水平没有差异。

Levels of CD5+ B lymphocytes do not differ between patients with myasthenia gravis and healthy individuals.

作者信息

Yi Q, Ahlberg R, Pirskanen R, Lefvert A K

机构信息

Immunological Research Laboratory, Karolinska Hospital, Stockholm, Sweden.

出版信息

Neurology. 1992 May;42(5):1081-4. doi: 10.1212/wnl.42.5.1081.

DOI:10.1212/wnl.42.5.1081

PMID:1374547

Abstract

CD5+ B cells might be involved in autoimmunity mainly as autoantibody-producing cells. To investigate the possible role of these cells in myasthenia gravis, we studied the numbers of CD5+ B cells, CD5- B cells, and CD19+ B cells as well as CD5+ T cells in the peripheral blood from 31 patients with myasthenia gravis and 31 healthy individuals. Both absolute percentages (percent of peripheral blood mononuclear cells) and relative percentages (percent of total CD19+ B cells) of CD5+ B cells were the same in patients as in controls. The numbers of CD5- B cells and CD19+ B cells were the same in both groups, whereas CD5+ T cells were lower in the patients. There was no correlation between clinical stage, sex, thymectomy, or pathology of thymus and the levels of CD5+ B cells, CD5- B cells, or CD19+ B cells. Patients treated with azathioprine had lower levels of CD5+ B cells than untreated patients and controls. Our results show that patients with myasthenia gravis have the same levels of CD5+ B cells as healthy individuals.

摘要

CD5⁺ B细胞可能主要作为自身抗体产生细胞参与自身免疫。为了研究这些细胞在重症肌无力中的可能作用，我们研究了31例重症肌无力患者和31名健康个体外周血中CD5⁺ B细胞、CD5⁻ B细胞、CD19⁺ B细胞以及CD5⁺ T细胞的数量。患者中CD5⁺ B细胞的绝对百分比（外周血单个核细胞的百分比）和相对百分比（总CD19⁺ B细胞的百分比）与对照组相同。两组中CD5⁻ B细胞和CD19⁺ B细胞的数量相同，而患者中的CD5⁺ T细胞较低。临床分期、性别、胸腺切除术或胸腺病理与CD5⁺ B细胞、CD5⁻ B细胞或CD19⁺ B细胞水平之间无相关性。接受硫唑嘌呤治疗的患者的CD5⁺ B细胞水平低于未治疗的患者和对照组。我们的结果表明，重症肌无力患者的CD5⁺ B细胞水平与健康个体相同。