Kondo S, Okamura S, Harada N, Ikematsu W, Kawasaki C, Fukuda T, Kubota A, Shimoda K, Harada M, Shibuya T
First Department of Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Cancer Res Clin Oncol. 1992;118(5):386-8. doi: 10.1007/BF01294444.
Among 63 cases of acute myeloid leukemia (AML), 14 were found to express the CD7 antigen, a cell surface marker usually found at an early stage during T lineage differentiation. The CD7-positive AML cases consisted of 5 cases of M1, 3 cases of M2, 3 cases of M4, 1 case of M5, 1 case of M6 and 1 case of M7. Among these 63 cases, the proportion of blast cells expressing the CD34 antigen was examined. The proportion of CD34-stained cells among the CD7-positive AML cases, although varying, was significantly larger than that among the CD7-negative AML cases (P less than 0.05). As the CD34 antigen was expressed on hematopoietic progenitor cells and was considered to reflect an early hematopoietic stage, the high proportion of cells expressing CD34 among the CD7-positive AML cases may support the notion that CD7-positive AML cells are immature.
在63例急性髓系白血病（AML）患者中，有14例被发现表达CD7抗原，这是一种通常在T细胞系分化早期阶段发现的细胞表面标志物。CD7阳性的AML病例包括M1型5例、M2型3例、M4型3例、M5型1例、M6型1例和M7型1例。在这63例患者中，检测了表达CD34抗原的原始细胞比例。CD7阳性AML病例中CD34染色细胞的比例虽有差异，但显著高于CD7阴性AML病例（P小于0.05）。由于CD34抗原在造血祖细胞上表达，并被认为反映造血早期阶段，CD7阳性AML病例中表达CD34的细胞比例较高可能支持CD7阳性AML细胞不成熟这一观点。
