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脊柱原发性尤因肉瘤的治疗选择:7例报告及文献综述

Treatment options in primary Ewing's sarcoma of the spine: report of seven cases and review of the literature.

作者信息

Sharafuddin M J, Haddad F S, Hitchon P W, Haddad S F, el-Khoury G Y

机构信息

Division of Neurosurgery, American University of Beirut Medical Center, Lebanon.

出版信息

Neurosurgery. 1992 Apr;30(4):610-8; discussion 618-9.

PMID:1374853
Abstract

Primary Ewing's sarcoma of the spine is reviewed, and seven cases are presented. Ewing's sarcoma of the spine is a rare condition that appears with a clinical triad of local pain, neurological deficit, and a palpable mass. The clinical picture, imaging characteristics, and management are discussed. The definitive management of Ewing's sarcoma of the spine, as in other locations, could include three main modalities: surgery, radiotherapy, and combination chemotherapy. In the presence of acute neurological decompensation, decompressive surgery via an appropriate approach should be performed. Because Ewing's sarcoma is usually sensitive to chemotherapy, initial chemotherapy, in neurologically stable patients, could be attempted first without surgical resection. Further management could then be gauged according to the response.

摘要

本文回顾了原发性脊柱尤因肉瘤,并报告了7例病例。脊柱尤因肉瘤是一种罕见疾病,表现为局部疼痛、神经功能缺损和可触及肿块的临床三联征。文中讨论了其临床表现、影像学特征及治疗方法。与其他部位的尤因肉瘤一样,脊柱尤因肉瘤的确定性治疗主要包括三种方式:手术、放疗和联合化疗。出现急性神经功能失代偿时,应通过适当的入路进行减压手术。由于尤因肉瘤通常对化疗敏感,对于神经功能稳定的患者,可先尝试初始化疗,暂不进行手术切除。然后根据反应来确定进一步的治疗方案。

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