González-Barón S, Jiménez-Vargas J, Marcó J, Ribas B
Rev Esp Fisiol. 1976 Dec;32(4):301-5.
Reproduction in female rats kept on artificial cycles of light/darkness, continuous lighting and continuous darkness, has been studied. Three weekly doses of p-chlorophenylalanine (p-CPA), 100 mg/kg, were given to half of the rats in each group during the two preconditioning months before copulation. An evaluation has been made of the insemination, fecundation, number of embryos, ovarian cycle and level of 5-HT in the hypothalamus. The administration of p-CPA had an inhibitory effect on the reproductive behavior, especially pronounced in rats kept under continuous lighting and under continuous darkness. The difference in 5-TH levels were greater among the groups kept on cycles of light/darkness without treatment and with p-CPA (0.05 greater than P greater than 0.01). The importance of 5-HT in the mechanisms of reproductive behavior is emphasized.
对处于人工光/暗循环、持续光照和持续黑暗条件下的雌性大鼠的繁殖情况进行了研究。在交配前的两个月预处理期内，每组一半的大鼠每周接受三次剂量为100毫克/千克的对氯苯丙氨酸（p-CPA）。对授精、受精、胚胎数量、卵巢周期以及下丘脑中5-羟色胺水平进行了评估。p-CPA的给药对生殖行为有抑制作用，在持续光照和持续黑暗条件下饲养的大鼠中尤为明显。未接受处理和接受p-CPA处理的处于光/暗循环条件下的大鼠组之间，5-羟色胺水平差异更大（0.05＞P＞0.01）。强调了5-羟色胺在生殖行为机制中的重要性。
