González-Barón S, Jiménez-Vargas J, Marcó J
Rev Esp Fisiol. 1975 Mar;31(1):63-8.
The effect of p-chlorophenylalanie (p-CPA) --300 mg/kg-- on reproduction has been studied in the female rat. Groups of animals were injected with a dose of 300 mg/kg of p-CPA 48 hours before proper copulation conditions at different moments along the ovarian cycle. Presence of spermatozoa in the vaginal frotis was negative in treated rats; in the control groups however, positivity was found in variable proportions according to the phase of the ovarian cycle: 30 ad 90% in diestrus and proestrus respectively. Treated animals showed continuous diestrus phases and diffuse luteinitation of the ovary. The results may indicate that a decrease of cerebral 5-HT, caused by p-CPA, lessens the reproductive behaviour of the female rat through mechanisms depending probably on the liberation of gonadrotrophins.
已对雌性大鼠研究了对氯苯丙氨酸（p-CPA）——300毫克/千克——对生殖的影响。在卵巢周期的不同时刻，于适当交配条件前48小时给动物组注射300毫克/千克的p-CPA剂量。经处理的大鼠阴道涂片中有精子呈阴性；然而，在对照组中，根据卵巢周期阶段发现阳性比例各不相同：在间情期和动情前期分别为30%和90%。经处理的动物表现出持续的间情期阶段和卵巢弥漫性黄体化。结果可能表明，p-CPA引起的脑5-羟色胺减少，可能通过依赖促性腺激素释放的机制降低雌性大鼠的生殖行为。
