在非静态条件下，体外单核细胞与活化的人血管内皮细胞的附着是由白细胞粘附分子-1（L-选择素）介导的。
Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions.
作者信息
Spertini O, Luscinskas F W, Gimbrone M A, Tedder T F
机构信息
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
出版信息
J Exp Med. 1992 Jun 1;175(6):1789-92. doi: 10.1084/jem.175.6.1789.
Abstract
The receptors that mediate monocyte adhesion to cytokine-stimulated endothelial monolayers were assessed using a nonstatic (rotating) cell-attachment assay. In this system, leukocyte adhesion molecule-1 (LAM-1) (L-selectin) mediated a major portion (87 +/- 15% at 37 degrees C) of monocyte attachment to activated endothelium. mAb blocking of endothelial leukocyte adhesion molecule-1 (41% inhibition), CD18 (36%), and vascular cell adhesion molecule-1 (25%) function had lesser effects on attachment. These results suggest that LAM-1 may serve an important role in monocyte attachment to endothelium at sites of inflammation.
摘要
使用非静态（旋转）细胞附着试验评估介导单核细胞黏附至细胞因子刺激的内皮单层的受体。在该系统中，白细胞黏附分子-1（LAM-1）（L-选择素）介导了大部分（37℃时为87±15%）单核细胞与活化内皮的附着。单克隆抗体阻断内皮白细胞黏附分子-1（抑制41%）、CD18（36%）和血管细胞黏附分子-1（25%）的功能对附着的影响较小。这些结果表明，LAM-1可能在炎症部位单核细胞与内皮的附着中起重要作用。
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