手术室工作人员的姐妹染色单体交换

Sister-chromatid exchanges in operating room personnel.

作者信息

Sardaş S, Cuhruk H, Karakaya A E, Atakurt Y

机构信息

University of Gazi, Department of Toxicology, Faculty of Pharmacy, Ankara, Turkey.

出版信息

Mutat Res. 1992 May 16;279(2):117-20. doi: 10.1016/0165-1218(92)90253-v.

DOI:10.1016/0165-1218(92)90253-v

PMID:1375336

Abstract

Sister-chromatid exchange (SCE) analysis was carried out in 67 operating room personnel (anaesthetists M.D.; anaesthesia nurses and anaesthesia unit technicians) exposed to waste anaesthetic gases such as halothane, nitrous oxide and isoflurane and in 50 healthy unexposed controls. The SCE frequencies were increased significantly in operating room personnel as compared to controls. A significant increase in SCEs was found in non-smoking operating room personnel as compared to non-smoking controls. This study supports the existence of an association between occupational exposure to mutagens and an increase in SCEs in lymphocytes.

摘要

对67名接触氟烷、氧化亚氮和异氟烷等麻醉废气的手术室工作人员（麻醉医生、麻醉护士和麻醉科技术员）以及50名未接触废气的健康对照者进行了姐妹染色单体交换（SCE）分析。与对照组相比，手术室工作人员的SCE频率显著增加。与不吸烟的对照者相比，不吸烟的手术室工作人员的SCE显著增加。本研究支持职业性接触诱变剂与淋巴细胞SCE增加之间存在关联。