Wilms G, Van Ongeval C, Baert A L, Claus A, Bollen J, De Cuyper H, Eneman M, Malfroid M, Peuskens J, Heylen S
Department of Radiology, University Hospital Gasthuisberg, Leuven, Belgium.
Acta Psychiatr Scand. 1992 Apr;85(4):306-12. doi: 10.1111/j.1600-0447.1992.tb01474.x.
The ventricle-brain ratio (VBR) of 42 chronic schizophrenic patients was compared with that of 42 age-matched medical controls. For the schizophrenics, the relationship of various clinical parameters to the VBR was assessed, and the outcome of 12 weeks of double-blind treatment with either risperidone or haloperidol. The results confirm that schizophrenic patients have slightly enlarged lateral ventricles compared with medical controls. Only for schizophrenics, an effect of age, but not of duration of illness, was noticed. This study does not support the validity of a clinical subdivision of chronic schizophrenic patients on the basis of the VBR. Neither negative, positive nor general psychopathological symptoms, as measured by the Positive and Negative Syndrome Scale for Schizophrenia (PANSS), were related to the VBR, nor were abnormal involuntary movements or extrapyramidal symptoms. No association between season of birth or a family history of major mental disorder and VBR could be demonstrated. Treatment response was predicted by the total PANSS score and the PANSS general psychopathology subscale score at baseline. There was a trend for patients with higher VBR to have a more or haloperidol). or haloperidol).
将42例慢性精神分裂症患者的脑室-脑比率（VBR）与42例年龄匹配的医学对照者进行比较。对于精神分裂症患者，评估了各种临床参数与VBR的关系，以及使用利培酮或氟哌啶醇进行12周双盲治疗的结果。结果证实，与医学对照者相比，精神分裂症患者的侧脑室略有扩大。仅在精神分裂症患者中，发现了年龄的影响，而非病程的影响。本研究不支持基于VBR对慢性精神分裂症患者进行临床细分的有效性。通过精神分裂症阳性和阴性症状量表（PANSS）测量的阴性、阳性或一般精神病理症状均与VBR无关，异常不自主运动或锥体外系症状也与VBR无关。未发现出生季节或重大精神障碍家族史与VBR之间存在关联。治疗反应可通过基线时的PANSS总分和PANSS一般精神病理学子量表得分来预测。VBR较高的患者有更……或氟哌啶醇）。或氟哌啶醇）的趋势。
