Weaver L T, Rosenthal S R, Gladstone W, Winter H S
Department of Pediatrics, Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Acta Paediatr. 1992 Jan;81(1):79-81. doi: 10.1111/j.1651-2227.1992.tb12085.x.
An infant with delayed development and peripheral myopathy, nourished on a soy-based liquid diet deficient in carnitine, had gastrointestinal dysmotility manifested by postprandial vomiting, oral drooling, delayed gastric emptying and infrequent bowel movements. Oesophageal manometry showed a reduced lower oesophageal sphincter pressure for age with abnormal distal motility. Serum carnitine concentration was 9.9 mumol l-1. After dietary supplementation of carnitine the gastrointestinal symptoms resolved, oesophageal manometry returned to normal, and serum carnitine increased to 37.2 mumol l-1. Dietary carnitine deficiency in infancy may be a cause of smooth muscle dysmotility of the gastrointestinal tract.
一名发育迟缓并患有周围性肌病的婴儿，食用缺乏肉碱的大豆基流食，出现了以餐后呕吐、流口水、胃排空延迟和排便不频繁为表现的胃肠动力障碍。食管测压显示，该婴儿的食管下括约肌压力低于同龄人，且远端动力异常。血清肉碱浓度为9.9μmol/L。补充肉碱后，胃肠道症状消失，食管测压恢复正常，血清肉碱升至37.2μmol/L。婴儿期膳食肉碱缺乏可能是胃肠道平滑肌动力障碍的一个原因。
