Chisholm R A, Dixon A K, Williams M V, Oliver R T
Department of Diagnostic Radiology, Addenbrooke's Hospital, Cambridge, U.K.
Cancer Chemother Pharmacol. 1992;30(2):158-60. doi: 10.1007/BF00686411.
A review of hard-copy computed tomography (CT) images of patients who had undergone chemotherapy for testicular teratoma revealed that the incidence of lung toxicity appeared to be lower in those who had received bleomycin by slow infusion [EBCi (3) regimen, etoposide/bleomycin/cisplatin] rather than by intravenous bolus [PVB regimen, cisplatin/vinblastine/bleomycin; BEP (5) regimen, bleomycin/etoposide/cisplatin]. This difference reached statistical significance only for PVB vs EBCi (3) (t = 2.63, P less than 0.01). Nevertheless, in view of continuing reports of mortality resulting from bleomycin-induced pulmonary fibrosis in patients receiving the drug by i.v. bolus, further exploration of these results is clearly justified.
对接受过睾丸畸胎瘤化疗的患者的硬拷贝计算机断层扫描（CT）图像进行回顾后发现，与通过静脉推注接受博来霉素的患者[PVB方案，顺铂/长春花碱/博来霉素；BEP（5）方案，博来霉素/依托泊苷/顺铂]相比，通过缓慢输注接受博来霉素的患者[EBCi（3）方案，依托泊苷/博来霉素/顺铂]肺部毒性的发生率似乎更低。仅PVB与EBCi（3）相比，这种差异具有统计学意义（t = 2.63，P小于0.01）。然而，鉴于持续有报告称接受静脉推注该药物的患者因博来霉素诱导的肺纤维化导致死亡，显然有理由对这些结果进行进一步探索。
