Bellamy E A, Husband J E, Blaquiere R M, Law M R
Radiology. 1985 Jul;156(1):155-8. doi: 10.1148/radiology.156.1.2408293.
Computed tomography (CT) examinations of the chest were evaluated in 100 patients treated with bleomycin. The CT findings were compared with those of conventional chest radiographs and lung-function tests. Lung damage due to bleomycin was detected in 38% of patients by CT, while damage was detected in only 15% by radiography. Changes in appearance seen on CT scans due to bleomycin damage were compared with measurements of lung volume and gas transfer per unit lung volume. There was good correlation between severity of damage shown on CT scans and changes in lung volume (P less than 0.01). Gas transfer capabilities were reduced in most patients regardless of changes observed on CT scans. Sequential CT studies showed that complete resolution of bleomycin damage may occur within 9 months in patients with minor or moderate damage. Residual abnormalities were seen in all patients with severe damage. CT can confirm lung damage in a patient with suspected toxicity but a normal chest radiograph and can define the anatomic extent of disease in a patient with an abnormal lung-function test.
对100例接受博来霉素治疗的患者的胸部计算机断层扫描（CT）检查结果进行了评估。将CT检查结果与传统胸部X线片及肺功能检查结果进行比较。CT检查发现38%的患者存在博来霉素所致的肺损伤，而X线片仅发现15%的患者有损伤。将CT扫描上因博来霉素损伤出现的外观变化与肺容积及单位肺容积气体交换量的测量结果进行比较。CT扫描显示的损伤严重程度与肺容积变化之间存在良好的相关性（P<0.01）。大多数患者的气体交换能力降低，无论CT扫描有无变化。连续CT研究表明，轻度或中度损伤患者的博来霉素损伤可能在9个月内完全消退。所有重度损伤患者均有残留异常。CT可在胸部X线片正常但怀疑有毒性的患者中证实肺损伤，并可在肺功能检查异常的患者中明确疾病的解剖范围。
