Giri A K
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
Mutat Res. 1992 Jul;277(1):1-9. doi: 10.1016/0165-1110(92)90023-3.
Aliphatic epoxides are a group of compounds extensively used in industry and as laboratory reagents, and can be produced as metabolic intermediates. An important aliphatic epoxide is propylene oxide, extensively used in the production of propylene glycol and polyols used in the manufacture of polyurethane polymers. The widespread human exposure to propylene oxide is of great health concern. In this review an attempt has been made to evaluate and update the genotoxic effects of propylene oxide and trichloropropylene oxide based on the available literature.
脂肪族环氧化物是一类在工业上广泛使用并用作实验室试剂的化合物，并且可作为代谢中间体产生。一种重要的脂肪族环氧化物是环氧丙烷，它广泛用于生产丙二醇和用于制造聚氨酯聚合物的多元醇。人类广泛接触环氧丙烷引起了极大的健康关注。在本综述中，已尝试根据现有文献评估并更新环氧丙烷和三氯环氧丙烷的遗传毒性效应。
