Månsson-Rahemtulla B, Techanitiswad T, Rahemtulla F, McMillan T O, Bradley E L, Wahlin Y B
Department of Community and Public Health Dentistry, University of Alabama School of Dentistry, Birmingham.
Oral Surg Oral Med Oral Pathol. 1992 Jan;73(1):35-46. doi: 10.1016/0030-4220(92)90151-f.
We analyzed several salivary components in stimulated whole saliva from patients with acute leukemia who were undergoing chemotherapy. Saliva samples were collected at the time of diagnosis and longitudinally during the treatment period. Data analyses showed that patients with leukemia had significantly higher peroxidase and amylase activity and elevated concentrations of total protein at the time of diagnosis. After induction chemotherapy these parameters returned to normal values and remained constant during the observation period. At the time of diagnosis no significant differences in thiocyanate (SCN-) concentrations were found in saliva samples from control subjects and patients with leukemia. Treatment with cytotoxic agents resulted in granulocytopenia and a concomitant decrease in the SCN- concentration in saliva. The function of the salivary peroxidase system is impaired by the decrease in SCN- concentration, which may be a contributing factor to some of the oral complications that occur in patients undergoing chemotherapy.
我们分析了正在接受化疗的急性白血病患者刺激全唾液中的几种唾液成分。在诊断时以及治疗期间纵向采集唾液样本。数据分析表明，白血病患者在诊断时过氧化物酶和淀粉酶活性显著更高，总蛋白浓度升高。诱导化疗后，这些参数恢复到正常水平，并在观察期内保持稳定。在诊断时，对照受试者和白血病患者的唾液样本中硫氰酸盐（SCN-）浓度没有显著差异。细胞毒性药物治疗导致粒细胞减少，同时唾液中SCN-浓度降低。唾液过氧化物酶系统的功能因SCN-浓度降低而受损，这可能是化疗患者发生某些口腔并发症的一个促成因素。
