Ashok L, Sujatha G P, Hema G
Department of Oral Medicine and Radiology, Bapuji Dental College and Hospital, Davangere, India.
Indian J Dent Res. 2010 Oct-Dec;21(4):486-90. doi: 10.4103/0970-9290.74212.
Leukemia is a fatal disease. The oral manifestations of the leukemias occur early in the course of the disease and these oral features can at times act as a diagnostic indicator. Saliva has been used as a diagnostic aid in a number of systemic diseases.
In our study, samples of unstimulated saliva of 30 leukemia patients who were not on chemotherapy were collected and analyzed for salivary amylase and total protein. The oral manifestations and radiographic changes (OPG) were recorded. The correlation between the oral manifestations and the salivary components (salivary amylase and total protein) was assessed for prognostic significance.
In the present study when the mean values of salivary amylase (1280±754 U/ml) and total protein (647.2±320.7 mg%) were compared with that in control subjects. There was a statistically significant difference for amylase levels (P<.05). On intraoral examination the study subjects showed pallor, gingivitis, gingival enlargement, petechiae, and ecchymosis. On the OPG, the radiographic features included generalized rarefaction of bone (20%), thinning of lamina dura (3.4%), generalized alveolar crest bone resorption (30%), thinning of walls of alveolar crypts (6.7%), besides others, e.g., periapical abscess (10%).
The saliva of leukemic patients demonstrated obvious changes in composition. A rise in salivary amylase and total protein levels was evident, with the increase in amylase levels being statistically significant.
白血病是一种致命疾病。白血病的口腔表现出现在疾病进程的早期，这些口腔特征有时可作为诊断指标。唾液已被用作多种全身性疾病的诊断辅助手段。
在我们的研究中，收集了30例未接受化疗的白血病患者的非刺激性唾液样本，并对唾液淀粉酶和总蛋白进行分析。记录口腔表现和影像学变化（全景片）。评估口腔表现与唾液成分（唾液淀粉酶和总蛋白）之间的相关性以判断其预后意义。
在本研究中，将唾液淀粉酶（1280±754 U/ml）和总蛋白（647.2±320.7 mg%）的平均值与对照组进行比较时，淀粉酶水平存在统计学显著差异（P<0.05）。口腔检查时，研究对象表现出面色苍白、牙龈炎、牙龈肿大、瘀点和瘀斑。在全景片上，影像学特征包括骨质普遍稀疏（20%）、硬骨板变薄（3.4%）、牙槽嵴普遍骨质吸收（30%）、牙槽窝壁变薄（6.7%），此外还有其他情况，如根尖周脓肿（10%）。
白血病患者的唾液成分有明显变化。唾液淀粉酶和总蛋白水平明显升高，其中淀粉酶水平的升高具有统计学意义。
