Emanuel A, Szucs S, Weier H U, Kovacs G
Laboratory of Cytogenetics, Institute of Pathology, Albert-Ludwigs-University, Freiburg, Federal Republic of Germany.
Genes Chromosomes Cancer. 1992 Jan;4(1):75-7. doi: 10.1002/gcc.2870040110.
By means of G-banding techniques, chromosome aberrations were studied in short-term cultures of normal renal parenchymal cells from 45 patients with renal cell carcinoma. Clonal chromosomal aberrations were detected in 29 patients; loss of the Y chromosome as well as trisomy X, 5, 7, 9, 10, 12, and 18 was found. Chromosomes 7 and 10 were involved preferentially. Results of fluorescence in situ hybridization with chromosome 7- and 10-specific DNA probes on non-cultured normal kidney cells suggested that the aberrations developed in vivo.
采用G显带技术，对45例肾细胞癌患者正常肾实质细胞的短期培养物进行染色体畸变研究。在29例患者中检测到克隆性染色体畸变；发现Y染色体缺失以及X、5、7、9、10、12和18号染色体三体。7号和10号染色体受累更为常见。用7号和10号染色体特异性DNA探针在未培养的正常肾细胞上进行荧光原位杂交的结果表明，这些畸变是在体内发生的。
