Kondo N, Fukutomi O, Kameyama T, Orii T
Department of Pediatrics, Gifu University School of Medicine, Japan.
Clin Exp Allergy. 1992 Apr;22(4):447-53. doi: 10.1111/j.1365-2222.1992.tb00146.x.
Experimental studies have shown that N(3',4'-dimethoxycinnamoyl) anthranilic acid (Tranilast) inhibits reaginic antibody-mediated hypersensitivity reactions, and it has been demonstrated to be an effective drug for patients with bronchial asthma. On the other hand, from the nature of the cellular infiltrate seen in eczematous lesions, it appears that some form of cell-mediated immunity may be involved in addition to IgE-mediated immunity in the pathogenesis of atopic dermatitis (AD). Moreover, we have previously reported that the proliferative responses of peripheral blood mononuclear cells (PBMCs) to ovalbumin (OA) or bovine serum albumin (BSA) in children with AD who are sensitive to hen's egg or cow's milk were significantly higher than those of healthy children and hen's egg or cow's milk sensitive children with immediate symptoms. In this study, we have showed that the proliferative responses of PBMCs to OA were dose-dependently inhibited by Tranilast on patients with AD. The responding cells to OA were shown, through separation experiments, to be T cells, and the proliferative responses of T cells to OA were also dose-dependently inhibited by Tranilast. Moreover, the inhibition was thought to occur at the initial stage of the proliferative reactions. These results suggest that Tranilast can be clinically applied to patients with AD.
实验研究表明，N-(3',4'-二甲氧基肉桂酰)邻氨基苯甲酸（曲尼司特）可抑制反应素抗体介导的超敏反应，并且已证明它对支气管哮喘患者是一种有效的药物。另一方面，从湿疹性病变中所见细胞浸润的性质来看，在特应性皮炎（AD）的发病机制中，除了IgE介导的免疫外，似乎还涉及某种形式的细胞介导免疫。此外，我们之前报道过，对鸡蛋或牛奶敏感的AD患儿外周血单个核细胞（PBMC）对卵清蛋白（OA）或牛血清白蛋白（BSA）的增殖反应明显高于健康儿童以及有速发型症状的鸡蛋或牛奶敏感儿童。在本研究中，我们表明曲尼司特对AD患者PBMC对OA的增殖反应具有剂量依赖性抑制作用。通过分离实验显示，对OA产生反应的细胞是T细胞，曲尼司特对T细胞对OA的增殖反应也具有剂量依赖性抑制作用。此外，这种抑制作用被认为发生在增殖反应的初始阶段。这些结果表明曲尼司特可在临床上应用于AD患者。
