Pal A K, Rahman M S, Chatterjee S N
Biophysics Division, Saha Institute of Nuclear Physics, Calcutta, India.
Mutat Res. 1992 Jul;280(1):67-71. doi: 10.1016/0165-1218(92)90019-v.
Several nitrofurans were found to induce umu gene expression in Salmonella typhimurium TA1535/pSK1002 as defined on the basis of at least a 2-fold increase of beta-galactosidase activity over the background level. beta-Galactosidase activity increased with increasing concentrations of the chemical, attained a maximum at a concentration which was different for different nitrofurans used, and then gradually decreased with a further increase of the nitrofuran concentration. The umu gene expression test revealed that the genotoxic activity was highest for furazolidone and lowest for 5-nitro-2-furaldehyde.
在鼠伤寒沙门氏菌TA1535/pSK1002中，发现几种硝基呋喃可诱导umu基因表达，这是根据β-半乳糖苷酶活性至少比背景水平增加2倍来定义的。β-半乳糖苷酶活性随化学物质浓度的增加而增加，在不同硝基呋喃所使用的不同浓度下达到最大值，然后随着硝基呋喃浓度的进一步增加而逐渐降低。umu基因表达试验表明，呋喃唑酮的遗传毒性活性最高，5-硝基-2-糠醛的遗传毒性活性最低。
