静脉注射木瓜蛋白酶使基质耗尽后，体外软骨对硫-35的固定增加。
Increased fixation of sulfur-35 by cartilage in vitro following depletion of the matrix by intravenous papain.
作者信息
MCELLIGOTT T F, POTTER J L
出版信息
J Exp Med. 1960 Nov 1;112(5):743-50. doi: 10.1084/jem.112.5.743.
Abstract
The uptake in vitro of sulfur-35 by costal cartilage obtained from nine rabbits 11 days after an intravenous injection of crude papain solution was compared with that in costal cartilage from eight normal untreated rabbits. An increased fixation of the isotope was found in treated animals compared with controls. The depletion of cartilage matrix by papain provided an experimental situation to test the hypothesis that the depletion of matrix which occurs in osteoarthritic cartilage can stimulate increased synthesis of chondroitin sulfate. The results give further support to the view that the primary lesion in osteoarthritis occurs in the matrix rather than in the chondrocyte of articular cartilage.
摘要
将静脉注射粗制木瓜蛋白酶溶液11天后从9只兔子获取的肋软骨对硫-35的体外摄取情况，与8只未经处理的正常兔子的肋软骨对硫-35的体外摄取情况进行了比较。结果发现，与对照组相比，经处理的动物体内同位素的固定增加。木瓜蛋白酶对软骨基质的消耗提供了一种实验情况，以检验以下假设：骨关节炎软骨中发生的基质消耗可刺激硫酸软骨素合成增加。这些结果进一步支持了以下观点，即骨关节炎的原发性病变发生在关节软骨的基质而非软骨细胞中。
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