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1
Increased fixation of sulfur-35 by cartilage in vitro following depletion of the matrix by intravenous papain.静脉注射木瓜蛋白酶使基质耗尽后，体外软骨对硫-35的固定增加。
J Exp Med. 1960 Nov 1;112(5):743-50. doi: 10.1084/jem.112.5.743.
2
Comparison of the effects of papain n vitamin A on cartilage. I. The effects in rabbits.木瓜蛋白酶和维生素A对软骨影响的比较。I. 对兔子的影响。
J Exp Med. 1960 May 1;111(5):705-18. doi: 10.1084/jem.111.5.705.
3
An autoradiographic study of the epiphyseal cartilage in papain-treated rabbits after administration of radiosulphate.给予放射性硫酸盐后木瓜蛋白酶处理的家兔骨骺软骨的放射自显影研究。
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Papain-induced mitosis of chondrocytes in adult joint cartilage: an experimental study in full-grown rabbits.木瓜蛋白酶诱导成年关节软骨细胞有丝分裂：对成年兔的实验研究
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The removal of cartilage matrix by papain. Factors affecting the distribution of crystalline papain in vivo.木瓜蛋白酶对软骨基质的去除。影响结晶木瓜蛋白酶在体内分布的因素。
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THE EFFECTS OF PAPAIN, VITAMIN A, AND CORTISONE ON CARTILAGE MATRIX IN VIVO.木瓜蛋白酶、维生素A和可的松对体内软骨基质的作用
Biophys J. 1964 Jan;4(1 Pt 2):SUPPL207-13. doi: 10.1016/s0006-3495(64)86939-3.
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The removal of cartilage matrix, in vivo, by papain; identification of crystalline papain protease as the cause of the phenomenon.木瓜蛋白酶在体内对软骨基质的去除；确定结晶木瓜蛋白酶是该现象的原因。
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Sulphate (35SO4) uptake by chondrocytes in relation to histological changes in osteoarthritic human articular cartilage.骨关节炎患者关节软骨中软骨细胞对硫酸盐（35SO4）的摄取与组织学变化的关系
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Altered chondrocytic oxidative metabolism during the restoration of depleted intercellular matrix.细胞外基质耗竭恢复过程中软骨细胞氧化代谢的改变
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The fine structure of proliferating cartilage cells: structural changes in an experimental model.增殖软骨细胞的精细结构：实验模型中的结构变化
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Changes in articular cartilage following intraarticular injection of tritiated glyceryl trioleate.关节内注射氚标记的三油酸甘油酯后关节软骨的变化。
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本文引用的文献

1
Quantitative differential fixation of sulfate by tissues maintained in vitro; sulfate fixation as a function of age for embryonic tissues.体外培养组织对硫酸盐的定量差异固定；胚胎组织硫酸盐固定与年龄的关系
Cancer. 1950 Jul;3(4):725-34. doi: 10.1002/1097-0142(1950)3:4<725::aid-cncr2820030418>3.0.co;2-7.
2
Labeled inorganic sulfate in the diagnosis of cartilaginous tumors and their metastases.放射性标记无机硫酸盐在软骨肿瘤及其转移瘤诊断中的应用
Cancer. 1949 Nov;2(6):1089-92. doi: 10.1002/1097-0142(194911)2:6<1089::aid-cncr2820020615>3.0.co;2-q.
3
Effect of thyroxine and thiouracil on S35 deposition in articular cartilage.甲状腺素和硫脲嘧啶对关节软骨中S35沉积的影响。
J Biol Chem. 1951 Apr;189(2):717-27.
4
Sulphate metabolism in the cartilage of the trachea, pinna and xiphoid process of the adult mouse as indicated by autoradiographs.放射自显影片所示成年小鼠气管、耳廓及剑突软骨中的硫酸盐代谢。
Exp Cell Res. 1955 Apr;8(2):336-44. doi: 10.1016/0014-4827(55)90145-2.
5
Chondrocyte function of human articular and costal cartilage compared by measuring the in vitro uptake of labelled (35S) sulphate.通过测量标记的（35S）硫酸盐的体外摄取来比较人关节软骨和肋软骨的软骨细胞功能。
Ann Rheum Dis. 1960 Mar;19(1):31-41. doi: 10.1136/ard.19.1.31.
6
Sulphate metabolism in cartilage. II. S35-sulphate uptake and total sulphate in cartilage slices.软骨中的硫酸盐代谢。II. 软骨切片对S35-硫酸盐的摄取及总硫酸盐含量
J Bone Joint Surg Am. 1960 Jan;42-A:165-72.
7
Turbidity produced by hexamminecobaltic chloride in serum of rabbits injected intravenously with papain.静脉注射木瓜蛋白酶的兔血清中六氨合氯化钴产生的浊度。
Proc Soc Exp Biol Med. 1959 Oct-Dec;102:584-7. doi: 10.3181/00379727-102-25326.
8
The effect of prolactin on S35 fixation in the costal cartilage of the hypophysectomized rat.催乳素对垂体切除大鼠肋软骨中S35固定的影响。
Endocrinology. 1959 Aug;65(2):147-51. doi: 10.1210/endo-65-2-147.
9
Aging and osteoarthritis of the human sternoclavicular joint.人类胸锁关节的老化与骨关节炎
Am J Pathol. 1959 Jul-Aug;35(4):851-65.
10
The removal of cartilage matrix in vivo by papain; prevention of recovery with cortisone, hydrocortisone and prednisoione by a direct action on cartilage.木瓜蛋白酶在体内对软骨基质的去除；可的松、氢化可的松和泼尼松龙通过对软骨的直接作用来防止恢复。
Am J Pathol. 1959 Jul-Aug;35(4):819-33.

静脉注射木瓜蛋白酶使基质耗尽后，体外软骨对硫-35的固定增加。

Increased fixation of sulfur-35 by cartilage in vitro following depletion of the matrix by intravenous papain.

作者信息

MCELLIGOTT T F, POTTER J L

出版信息

J Exp Med. 1960 Nov 1;112(5):743-50. doi: 10.1084/jem.112.5.743.

DOI:10.1084/jem.112.5.743
PMID:13773897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2137303/
Abstract

The uptake in vitro of sulfur-35 by costal cartilage obtained from nine rabbits 11 days after an intravenous injection of crude papain solution was compared with that in costal cartilage from eight normal untreated rabbits. An increased fixation of the isotope was found in treated animals compared with controls. The depletion of cartilage matrix by papain provided an experimental situation to test the hypothesis that the depletion of matrix which occurs in osteoarthritic cartilage can stimulate increased synthesis of chondroitin sulfate. The results give further support to the view that the primary lesion in osteoarthritis occurs in the matrix rather than in the chondrocyte of articular cartilage.

摘要

将静脉注射粗制木瓜蛋白酶溶液11天后从9只兔子获取的肋软骨对硫-35的体外摄取情况，与8只未经处理的正常兔子的肋软骨对硫-35的体外摄取情况进行了比较。结果发现，与对照组相比，经处理的动物体内同位素的固定增加。木瓜蛋白酶对软骨基质的消耗提供了一种实验情况，以检验以下假设：骨关节炎软骨中发生的基质消耗可刺激硫酸软骨素合成增加。这些结果进一步支持了以下观点，即骨关节炎的原发性病变发生在关节软骨的基质而非软骨细胞中。