论核糖核酸在动物病毒合成中的作用。II. 核糖核酸酶的研究

On the role of ribonucleic acid in animal virus synthesis. II. Studies with ribonuclease.

作者信息

TAMM I, BABLANIAN R

出版信息

J Exp Med. 1960 Mar 1;111(3):351-68. doi: 10.1084/jem.111.3.351.

DOI:10.1084/jem.111.3.351

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2137258/

Abstract

Ribonuclease is a highly active inhibitor of vaccinia virus multiplication in vitro in the chorioallantoic membrane removed from embryonated chicken eggs. It is also a highly active inhibitor of pock formation by vaccinia and herpes simplex viruses on the chorioallantoic membrane in vivo. Marked inhibitory effects were obtained with 12.5 microg. of RNase. However, complete inhibition was not obtained with several hundred micrograms of the enzyme. RNase caused no inactivation of the infectivity of vaccinia virus particles but it had a marked inhibitory effect on multiplication of this virus when administered many hours after infection of host cells had occurred. RNase also failed to inactivate the infectivity of herpes simplex virus particles. The results obtained indicate that ribonucleic acid is necessary for the multiplication of two DNA-containing viruses; i.e., vaccinia and herpes simplex.

摘要

核糖核酸酶是痘苗病毒在从受精鸡蛋取出的绒毛尿囊膜上进行体外增殖的一种高效活性抑制剂。它也是痘苗病毒和单纯疱疹病毒在体内绒毛尿囊膜上形成痘疱的高效活性抑制剂。12.5微克核糖核酸酶产生了显著的抑制作用。然而，几百微克这种酶并未产生完全抑制作用。核糖核酸酶不会使痘苗病毒颗粒的感染性失活，但在宿主细胞感染数小时后给药时，它对该病毒的增殖有显著抑制作用。核糖核酸酶也未能使单纯疱疹病毒颗粒的感染性失活。所得结果表明，核糖核酸对于两种含DNA病毒即痘苗病毒和单纯疱疹病毒的增殖是必需的。

相似文献

1

On the role of ribonucleic acid in animal virus synthesis. II. Studies with ribonuclease.

J Exp Med. 1960 Mar 1;111(3):351-68. doi: 10.1084/jem.111.3.351.

2

Behaviour of DNase and RNase in the chorioallantoic membranes of chick embryos infected with vaccinia virus and herpes.

Boll Ist Sieroter Milan. 1957 Sep-Oct;36(9-10):574-8.

3

[Investigations concerning the action of several viruses on Ehrlich's ascitic carcinoma. I. The action of herpes virus and vaccinia virus].

Stud Cercet Inframicrobiol. 1961;12:223-8.

4

[The action of vaccinia and herpes viruses and of the cytostatic drugs, degranol and TEM, on several experimental pulmonary tumors].

Stud Cercet Inframicrobiol. 1961;12:317-23.

5

Effect of actinomycin D on cellular nucleic acid synthesis and virus production.

Science. 1961 Aug 25;134(3478):556-7. doi: 10.1126/science.134.3478.556.

6

Physical studies on pox viruses. I. Inactivation of vaccinia virus infectivity with low-energy electrons.

Biophys J. 1960 Sep;1(1):43-53. doi: 10.1016/s0006-3495(60)86874-9.

7

On the role of ribonucleic acid in animal virus synthesis. I. Studies with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

J Exp Med. 1960 Mar 1;111(3):339-49. doi: 10.1084/jem.111.3.339.

8

Effect of interferon on experimental vaccinia and herpes-simplex virus infections in rabbits' eyes.

Lancet. 1960 Sep 24;2(7152):682-4. doi: 10.1016/s0140-6736(60)91751-7.

9

Artificial ribonucleases inactivate a wide range of viruses using their ribonuclease, membranolytic, and chaotropic-like activities.

Antiviral Res. 2016 Sep;133:73-84. doi: 10.1016/j.antiviral.2016.07.014. Epub 2016 Jul 28.

10

The viral range in vitro of a malignant human epithelial cell (strain HeLa, Gel). I. Multiplication of herpes simplex, pseudorabies, and vaccinia viruses.

Am J Pathol. 1954 Nov-Dec;30(6):1057-73.

引用本文的文献

1

Effect of 8-azaguanine on the synthesis of vaccinia virus.

Br J Exp Pathol. 1962 Dec;43(6):587-95.

2

Poliovirus-induced RNA polymerase and the effects of virus-specific inhibitors on its production.

Proc Natl Acad Sci U S A. 1963 Jun;49(6):843-9. doi: 10.1073/pnas.49.6.843.

3

Observations on the fine structure of mature herpes simplex virus and on the composition of its nucleoid.

J Exp Med. 1962 Jan 1;115(1):1-12. doi: 10.1084/jem.115.1.1.

4

On the role of ribonucleic acid in animal virus synthesis. I. Studies with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

J Exp Med. 1960 Mar 1;111(3):339-49. doi: 10.1084/jem.111.3.339.

5

Demonstration of the sequential development of vaccinial antigens and virus in infected cells: observations with cytochemical and differential fluorescent procedures.

J Exp Med. 1961 Jul 1;114(1):149-60. doi: 10.1084/jem.114.1.149.

本文引用的文献

1

ISOLATION OF ADENOSINE AMINO ACID ESTERS FROM A RIBONUCLEASE DIGEST OF SOLUBLE, LIVER RIBONUCLEIC ACID.

Proc Natl Acad Sci U S A. 1958 Sep 15;44(9):885-9. doi: 10.1073/pnas.44.9.885.

2

Cytochemical studies on the intranuclear inclusion of herpes simplex.

J Immunol. 1950 Jul;65(1):119-28.

3

Action of ribonuclease and ribonucleic acid on living amoebae.

Nature. 1955 May 14;175(4463):851-3. doi: 10.1038/175851a0.

4

New observations on the mode of action of ribonuclease on living root-tips.

Biochim Biophys Acta. 1959 Oct;35:580-1. doi: 10.1016/0006-3002(59)90426-3.

5

On the role of ribonucleic acid in animal virus synthesis. I. Studies with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

J Exp Med. 1960 Mar 1;111(3):339-49. doi: 10.1084/jem.111.3.339.

6

Quantitative studies on the growth of herpes virus in HeLa cells.

J Gen Microbiol. 1958 Oct;19(2):250-66. doi: 10.1099/00221287-19-2-250.

7

The action of ribonuclease on the multiplication of influenza viruses in the de-embryonated egg.

Aust J Exp Biol Med Sci. 1957 Dec;35(6):517-29. doi: 10.1038/icb.1957.54.

8

Intermediate reactions in protein biosynthesis.

Biochim Biophys Acta. 1957 Apr;24(1):215-6. doi: 10.1016/0006-3002(57)90175-0.

9

Relationship between structure of benzimidazole derivatives and inhibitory activity on vaccinia virus multiplication.

Virology. 1957 Feb;3(1):185-96. doi: 10.1016/0042-6822(57)90032-6.

10

Multiplication of vaccinia virus in the chorioallantoic membrane in vitro.

Virology. 1957 Feb;3(1):173-84. doi: 10.1016/0042-6822(57)90031-4.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。