核糖核酸在动物病毒合成中的作用。I. 5,6-二氯-1-β-D-呋喃核糖基苯并咪唑的研究
On the role of ribonucleic acid in animal virus synthesis. I. Studies with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.
作者信息
TAMM I, NEMES M M, OSTERHOUT S
出版信息
J Exp Med. 1960 Mar 1;111(3):339-49. doi: 10.1084/jem.111.3.339.
Abstract
Adenosine, but not guanosine, was capable of blocking the inhibitory effect of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) on influenza virus multiplication in the chorioallantoic membrane in vitro. At virus inhibitory concentrations DRB caused marked inhibition in uptake of adenosine-8-C(14) into RNA of uninfected host cells, but it had little effect on uptake of C(14)-L-alanine into host cell proteins or on cellular oxygen consumption. The activity of DRB in inhibiting multiplication of the DNA-containing adenovirus was similar to its inhibitory activity on multiplication of the RNA-containing influenza virus. These and earlier results are discussed from the point of view of the important role of RNA in the reproduction of DNA-containing viruses.
摘要
腺苷而非鸟苷能够阻断5,6 - 二氯 - 1 - β - D - 呋喃核糖基苯并咪唑（DRB）对流感病毒在体外尿囊绒毛膜中增殖的抑制作用。在病毒抑制浓度下，DRB显著抑制未感染宿主细胞RNA对腺苷 - 8 - C¹⁴的摄取，但对C¹⁴ - L - 丙氨酸摄取到宿主细胞蛋白质中或对细胞耗氧量影响很小。DRB抑制含DNA的腺病毒增殖的活性与其对含RNA的流感病毒增殖的抑制活性相似。从RNA在含DNA病毒复制中的重要作用的角度对这些及早期结果进行了讨论。
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Measurement of oxygen uptake under controlled pressures of carbon dioxide.在二氧化碳控制压力下对氧摄取量的测量。
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J Exp Med. 1960 Mar 1;111(3):351-68. doi: 10.1084/jem.111.3.351.
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Glycosides of chlorobenzimidazoles as inhibitors of poliovirus multiplication.氯苯并咪唑糖苷作为脊髓灰质炎病毒增殖抑制剂
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Relationship between structure of benzimidazole derivatives and inhibitory activity on vaccinia virus multiplication.苯并咪唑衍生物的结构与对痘苗病毒增殖的抑制活性之间的关系。
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Protein synthesis in isolated cell nuclei.分离细胞核中的蛋白质合成。
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Antiviral chemotherapy.抗病毒化疗
Yale J Biol Med. 1956 Sep;29(1):33-49.
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