放线菌素D对细胞核酸合成及病毒产生的影响。
Effect of actinomycin D on cellular nucleic acid synthesis and virus production.
作者信息
REICH E, FRANKLIN R M, SHATKIN A J, TATUM E L
出版信息
Science. 1961 Aug 25;134(3478):556-7. doi: 10.1126/science.134.3478.556.
PMID:13740412
Abstract
Actinomycin D inhibits the synthesis of ribonucleic acid in L cells and the yield of vaccinia virus containing deoxyribonucleic acid, but it does not inhibit cellular deoxyribonucleic acid synthesis or the multiplication of Mengo virus containing ribonucleic acid. These observations serve to distinguish the replication of viral ribonucleic from ribonucleic acid synthesis which is controlled by viral or cellular deoxyribonucleic acid.
摘要
放线菌素D抑制L细胞中核糖核酸的合成以及含脱氧核糖核酸的痘苗病毒的产量，但它不抑制细胞脱氧核糖核酸的合成或含核糖核酸的门戈病毒的增殖。这些观察结果有助于区分病毒核糖核酸的复制与受病毒或细胞脱氧核糖核酸控制的核糖核酸合成。
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