Leslie M D, Dische S
Mount Vernon Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Radiother Oncol. 1992 May;24(1):27-31. doi: 10.1016/0167-8140(92)90350-4.
The changes in serum amylase that occur when radiotherapy is given in the treatment of head and neck cancer has been studied in 41 patients, 29 treated by CHART and 12 by conventionally fractionated radiotherapy. The peak rise in serum amylase following the start of treatment is seen earlier and is greater in the patients receiving continuous hyperfractionated accelerated radiotherapy (CHART). The serum amylase returns to normal earlier in the CHART patients so that the area under the curve is the same for both groups. The difference probably reflects the more rapid delivery of treatment to the patients receiving CHART. A close correlation between the peak rise in serum amylase and the amount of parotid tissue in the treatment volume is demonstrated. For six patients the total amount of amylase secreted by the parotid gland during CHART was measured and found to decline rapidly within a few days of the start of radiotherapy. The rise in serum amylase that results from the irradiation of salivary tissue provides a unique biochemical measure of an early radiation effect in a normal tissue. This probably reflects the interphase cell death of serous salivary cells. Although these immediate changes are of considerable interest they may not relate to the late effects of radiation on salivary gland function.
对41例头颈部癌患者进行放射治疗时血清淀粉酶的变化进行了研究，其中29例采用加速超分割放疗（CHART），12例采用常规分割放疗。治疗开始后血清淀粉酶的峰值升高在接受连续超分割加速放疗（CHART）的患者中出现得更早且更高。CHART组患者的血清淀粉酶恢复正常更早，因此两组曲线下面积相同。这种差异可能反映了CHART组患者接受治疗的速度更快。血清淀粉酶的峰值升高与治疗体积内腮腺组织的量之间存在密切相关性。对6例患者在CHART治疗期间腮腺分泌的淀粉酶总量进行了测量，发现放疗开始后几天内迅速下降。唾液组织受照射导致的血清淀粉酶升高为正常组织早期放射效应提供了一种独特的生化指标。这可能反映了浆液性唾液细胞的间期细胞死亡。尽管这些即时变化很有趣，但它们可能与辐射对唾液腺功能的晚期影响无关。
