Ramya Atmakuri Shanmukha, Uppala Divya, Majumdar Sumit, Surekha Ch, Deepak K G K
Post Graduate Student, Department of Oral Pathology and Microbiology, Gitam Dental College, Rushikonda, Vishakhapatnam, 530045, India.
Assistant Professor, Department of Oral Pathology and Microbiology, Gitam Dental College, Rushikonda, Vishakhapatnam, 530045, India.
J Oral Biol Craniofac Res. 2015 May-Aug;5(2):81-5. doi: 10.1016/j.jobcr.2015.04.002. Epub 2015 May 23.
Saliva, "Mirror of body's health" has long been of particular interest as a substitute for blood for disease diagnosis and monitoring. The radiation effects on salivary glands are of particular interest in which salivary amylase is a good indicator of salivary glands function. Thus, estimation of these parameters represents a reasonable approach in evaluation of patient's risk for disease occurrence, intensity and prognosis.
To evaluate and compare the pH and amylase levels in saliva of cancer patients prior to treatment, patients during treatment.
Saliva samples of 90 individuals were taken which were divided into 3 groups - 30 individuals without cancer, 30 cancer patients prior treatment and 30 cancer patients during treatment. Materials used were pH strips and pH meter, Salivary Amylase assay.
Statistical analysis - ANOVA with post-hoc Tukey's test. 1) Significant decrease in salivary amylase levels - in cancer patients, during treatment when compared to others. 2) Significant decrease in salivary pH levels in newly diagnosed cancer patients prior to treatment.
To conclude, pH strips and pH meter showed to be a useful tool in the measurement of pH of saliva in individuals with and without cancer. This study showed that cancer patients without treatment have a lower pH of saliva. Treatment increased the pH of the saliva to a more alkaline level whereas amylase levels decreased in those subjects. Therefore those parameters can be an area of further research with an increased sample size, which in-turn may help in opening the doors for new dimension in non invasive prognostic markers.
唾液作为“人体健康的镜子”，长期以来一直备受关注，有望替代血液用于疾病诊断和监测。辐射对唾液腺的影响尤其令人关注，其中唾液淀粉酶是唾液腺功能的良好指标。因此，评估这些参数是评估患者疾病发生风险、严重程度和预后的合理方法。
评估并比较癌症患者治疗前、治疗期间唾液的pH值和淀粉酶水平。
采集了90名个体的唾液样本，分为3组——30名无癌症个体、30名癌症治疗前患者和30名癌症治疗期间患者。使用的材料有pH试纸、pH计和唾液淀粉酶检测试剂盒。
统计分析——采用方差分析及事后Tukey检验。1）与其他组相比，癌症患者在治疗期间唾液淀粉酶水平显著降低。2）新诊断的癌症患者在治疗前唾液pH值显著降低。
总之，pH试纸和pH计被证明是测量有癌症和无癌症个体唾液pH值的有用工具。本研究表明，未经治疗的癌症患者唾液pH值较低。治疗使唾液pH值升高至更碱性水平，而这些受试者的淀粉酶水平降低。因此，这些参数可以作为一个进一步研究的领域，增加样本量，这反过来可能有助于为非侵入性预后标志物的新维度打开大门。
