Yamamoto M, Ujike H, Kohira I, Ogasawara N, Ogawa N
Department of Neurology, Kagawa Central Hospital.
Rinsho Shinkeigaku. 1992 Mar;32(3):272-5.
Neurochemical abnormalities in the patients with progressive supranuclear palsy (PSP) are not well understood. We investigated CSF levels of the monoamine metabolites HVA, 5HIAA and MHPG in 5 patients with PSP in order to investigate, especially dopaminergic, serotonergic and noradrenergic metabolism. Results were as follows (value; mena +/- S.D.). [table: see text] The levels of HVA were significantly lower than those in controls. These findings suggest that there is a hypofunction of dopaminergic neurons in PSP patients.
进行性核上性麻痹（PSP）患者的神经化学异常尚未完全明确。我们调查了5例PSP患者脑脊液中单胺代谢产物高香草酸（HVA）、5-羟吲哚乙酸（5HIAA）和3-甲氧基-4-羟基苯乙二醇（MHPG）的水平，以研究特别是多巴胺能、5-羟色胺能和去甲肾上腺素能代谢。结果如下（数值；均值±标准差）。[表格：见正文]HVA水平显著低于对照组。这些发现提示PSP患者存在多巴胺能神经元功能减退。
